| 创伤合并SIRS患者血清α-MSH与APACHEⅡ评分的关系 |
| 投稿时间：2011-05-04 修订日期：2011-05-17 点此下载全文 |
| 引用本文：周强,冯贵龙,杨晓明,杜晓东.创伤合并SIRS患者血清α-MSH与APACHEⅡ评分的关系[J].医学研究杂志,2012,41(1):104-106 |
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| 中文摘要:目的探讨创伤患者血清α-MSH与APACHE Ⅱ评分的关系及在病程监测中的意义。方法选择50例创伤合并全身炎症反应综合征（SIRS）患者，按照入院时APACHE Ⅱ评分分为轻度创伤组(22例, ≤15分)和重度创伤组(28例, >15分)，分别在入院的第1、3、5、7天动态检测血清α-MSH浓度的变化，采用酶联免疫吸附试验(ELISA)检测血清α-MSH含量，并同步进行APACHE Ⅱ评分，对所得结果进行统计学分析。结果患者入院时轻度创伤组与重度创伤组比较，血清α-MSH含量水平差异有统计学意义(P<0.05)；两组患者血清α-MSH水平随后变化不明显，重度组保持在较低水平，两组间同一时间点比较，差异有统计学意义(P<0.01或P<0.05)。入院时APACHEII评分两组间有差别，此后两组间APACHE Ⅱ评分各时间点比较，差异有统计学意义(P<0.01或P<0.05)。结论动态检测创伤患者血清α-MSH水平结合APACHE Ⅱ同步评分，有助于准确及时地评估病情。 |
| 中文关键词:α-MSH APACHE Ⅱ评分 SIRS |
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| Relationship between Serum α-MSH and APACHE Ⅱ Score in Trauma Patients |
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| Abstract:ObjectiveTo investigate the relationship between serum α-MSH and APACHE Ⅱ score in Trauma patients. Methods A clinical prospective self-control trial was performed. 50 patients with SIRS were enrolled, and were divided into mild (≤15) or severe trauma group(>15) according to APACHE Ⅱ score．The α-MSH concentrations were determined on the 1st, 3rd, 5th,7th day after admission and the APACHE Ⅱ score were assessed at the same time．The concentrations of α-MSH measured by enzyme linked immunosorbent assay (ELISA). ResultsThe concentrations of α-MSH in severe trauma group were higher than those in the mild trauma groups after trauma (P<0.05)．Then serum α-MSH level in the two groups did not change significantly, and the severe group remain low. There was significant difference (P<0.01 or P<0.05) in the indexes between the two groups at the same time. The APACHEⅡ score was significantly different between the two groups after trauma. Then APACHE Ⅱ score in the two groups had a significant difference (P<0.01 or P<0.05).ConclusionDynamic measurement of α-MSH concentrations with APACHE Ⅱ scores can help evaluate the severity of critical patients. |
| keywords:α-MSH APACHE Ⅱ SIRS |
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