| 组织蛋白酶D对口腔鳞癌中VEGF-C和VEGF-D的影响及淋巴管生成作用的研究 |
| 投稿时间：2011-04-09 修订日期：2011-04-19 点此下载全文 |
| 引用本文：胡振宇.组织蛋白酶D对口腔鳞癌中VEGF-C和VEGF-D的影响及淋巴管生成作用的研究[J].医学研究杂志,2012,41(1):130-132 |
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| 中文摘要:目的检测组织蛋白酶D（Cath-D）对口腔鳞癌中血管内皮生长因子-C（VEGF-C）和血管内皮生长因子-D（VEGF-D）表达的影响，探讨其对淋巴管生成的作用。方法选择86例口腔鳞癌标本作为观察组，收集60例正常口腔黏膜组织作为对照组，应用流式细胞分析Cath-D、VEGF-C和VEGF-D蛋白在两组中的表达，关注其表达的相关性及临床价值。结果口腔鳞癌中Cath-D、VEGF-C和VEGF-D高表达，口腔鳞癌中Cath-D、VEGF-C和VEGF-D的表达与肿瘤的分化程度、炎细胞浸润及淋巴结转移的差别有统计学意义。口腔鳞癌中Cath-D与VEGF-C、Cath-D与VEGF-D均呈正相关。结论 口腔鳞癌中Cath-D、VEGF-C和VEGF-D表达明显增加，Cath-D能促进VEGF-C和VEGF-D的表达，进而促进淋巴管的生成。联合检测Cath-D、VEGF-C和VEGF-D的表达可能对判断肿瘤的预后有参考价值。 |
| 中文关键词:口腔鳞癌 组织蛋白酶D VEGF-C VEGF-D 流式细胞术 |
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| Clinical Study of Lymphangiogenesis of Cath-D in Oral Squamous Cell Carcinoma |
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| Abstract:ObjectiveTo detect the expressions of Cath-D, VEGF-C and VEGF-D in oral squamous cell carcinoma, study their clinical significance and relationship, for directing clinical work.MethodsThe observation group included 86 cases of oral squamous cell cell carcinoma, and the control group included 60 cases of normal oral mucosa. The expressions of Cath-D, VEGF-C and VEGF-D were detected in two groups by flow cytometry. We analyzed their clinical significance and relationship in the observation group. ResultsThe expressions of Cath-D, VEGF-C and VEGF-D were obviously higher in the observation group than those in the control group. The expressions of Cath-D, VEGF-C and VEGF-D were obviously different in differention, inflammation and lymph node metastasis in the observation group. There was positive correlationship between Cath-D and VEGF-C, Cath-D and VEGF-D in oral squamous cell carcinoma. ConclusionThe higher expressions of Cath-D, VEGF-C and VEGF-D may promote the development of oral squamous cell carcinoma. Cath-D can promote the pathway of VEGF-C＼VEGF-D, induce the lymphangiogenesis in neoplasm. The expressions of Cath-D, VEGF-C and VEGF-D may be significant prognostic indicators in oral squamous cell carcinoma. |
| keywords:Oral squamous cell carcinoma Cath-D VEGF-C VEGF-D flow cytometry(FCM) |
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