| COMTval158met 基因多态性对抑郁症易感性的影响及抗抑郁剂疗效相关性研究 |
| 投稿时间：2011-05-12 修订日期：2011-06-01 点此下载全文 |
| 引用本文：林敏,沈鑫华,钱敏才,袁勇贵,孙菊水,钟华,杨剑虹,李良,关铁峰,沈仲夏.COMTval158met 基因多态性对抑郁症易感性的影响及抗抑郁剂疗效相关性研究[J].医学研究杂志,2012,41(2):81-84 |
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| 基金项目:2007年浙江省科技计划面上项目（2007C33043） |
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| 中文摘要:目的探讨儿茶酚胺氧位甲基转移酶(COMTval158met)基因多态性和抑郁症的发病及抗抑郁剂临床疗效的相关性。 方法对275例抑郁症患者采用随机数字表法给予文拉法辛缓释剂或帕罗西汀片治疗6周；于治疗前和治疗1、2、4及6周后采用汉密尔顿抑郁量表(HAMD17 )评定抑郁严重程度和疗效；抽取所有患者及202例正常对照组的静脉血，采用聚合酶链反应-限制性片段长度的多态性（PCR-RFLP）方法检测COMTval158 met各突变点基因多态性并进行基因分型。结果研究组的Met/Met、Val/Met、Val/Val基因型及Met、Val等位基因频率和正常对照组的差异无显著性（P均＞0.05）。两治疗组的痊愈组和非痊愈组之间及和正常对照组的COMTval158met等位基因频率和基因型频率差异均无显著性(P均＞0.05)。 结论COMTval158me基因多态性可能和抑郁症的发生、疗效无关联性。 |
| 中文关键词:抑郁症 儿茶酚胺氧位甲基转移酶 基因多态性 疗效 |
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| Association between Polymorphism of the COMTva1158met and Susceptivity of Depression and Efficacy of Antidepressant |
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| Abstract:ObjectiveTo explore the association between va1158met polymorphism in the catechol-O-methyl-transferase gene and onset of depression and efficacy of antidepressant. MethodsTotally 275 depression patients were randomly digits table assigned to venlafaxine or paroxetine treated for 6 weeks. The severity and efficacy was assessed with the Hamilton rating scale for depression before and after 1, 2, 4 and 6 week antidepressant treatment.The polymorphism of the COMTva1158met was analyzed by using polymerase chain reaction-restriction fragment length polymorphism in depression patients and 202 normal controls. ResultsThere was no significant difference in the frequency of Met/Met,Val/Met,Val/Val genotype and Met,Val allele between the research group and normal group(P＞005). There was no significant difference in the polymorphism of the COMTva1158met among the remission group,the non-remission group and normal controls (P＞0.05).ConclusionPolymorphism of the COMTva1158met may be not associated with onset of depression and efficacy of antidepressant. |
| keywords:Depression Catechol-O-methyl-transferase Gene polymorphism Efficacy |
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