| CXCR4和MMP-9在胃癌组织中表达及其意义 |
| 投稿时间：2011-05-30 修订日期：2011-06-13 点此下载全文 |
| 引用本文：徐斌,韩绍伟,周笑珍,蒋平,李利义.CXCR4和MMP-9在胃癌组织中表达及其意义[J].医学研究杂志,2012,41(2):104-108 |
| DOI：
|
| 摘要点击次数: 1217 |
| 全文下载次数: 981 |
|
| 基金项目:温州市科技计划基金资助项目（Y20090061）；温州市瓯海区科技计划项目（20090137） |
|
| 中文摘要:目的探讨趋化因子受体4(CXCR4)和基质金属蛋白酶-9 (MMP-9)在胃癌中的表达和临床意义。方法应用S-P免疫组织化学方法检测CXCR4和MMP-9在76例胃癌组织及癌旁正常胃组织中的表达水平，并分析其与胃癌临床病理因素之间的相关性。结果CXCR4在癌旁正常胃组织中无阳性表达，在胃癌组织中的阳性表达率为55.26%；CXCR4在伴有淋巴结转移与无淋巴结转移的胃癌组织中阳性表达率分别为73.91%和36.37%，差异有统计学意义(P=0.000)；CXCR4在伴有腹膜转移的胃癌组织中阳性表达表达率为100%，显著高于无腹膜转移组(39.28%，P=0.000)，且同肿瘤的分化程度及浸润深度关系密切（P分别为0.000、0.001）。MMP-9在胃癌组织中阳性表达率（67.11%）明显高于癌旁正常胃组织（15.79%）（P<0000）；MMP-9的在胃癌中的阳性表达与肿瘤组织分化程度、浸润深度、伴淋巴结转移及腹膜转移有关（P分别为0.002、0013、0.002、0.000）。CXCR4与MMP-9的阳性表达呈正相关(r=0.406, P=0.000)。结论CXCR4和MMP-9表达强度与胃癌的恶性程度密切相关。 |
| 中文关键词:胃癌 趋化因子受体4 基质金属蛋白酶9 临床病理因素 |
| |
| Expression of CXCR4 and MMP-9 in Gastric Cancer and Its Significance |
|
|
| Abstract:ObjectiveTo investigate the relationship between the expression of CXCR4 and MMP-9 in gastric cancer and several clinicopathological factors. MethodsA total of 76 cases of gastric cancer were enrolled in this study. Immunohistochemical staining was performed to detect the expression of CXCR4 and MMP-9 in gastric cancer. And statistical analysis technique was used to investigate the relationship between CXCR4 and MMP-9 expressions and the clinicopathological factors. ResultsThe total positive rate of CXCR4 expression in these samples was 55.26%, but there was no positive expression in the normal stomach tissue. The positive expression of CXCR4 was higher in these cases with lymphnode metastasis than that of patients without lymphnode metastasis (73.91% vs 36.37%, P=0.000). The positive rate of CXCR4 expression in these cases with peritoneal metastasis was higher than that of patients without peritoneal metastasis (100% vs 39.28%, P<0.000). Meanwhile, the positive rate of MMP-9 expression in normal stomach tissue and gastric cancer tissues were 15.79% and 67.11%, respectively. The positive expression of MMP-9 was higher in these cases with lymph node metastasis than that of patients without lymph node metastasis (80.43% vs 46.67%, P=0.002). Furthermore, the positive expression of MMP-9 with peritoneal transfer group was higher than that of patients without peritoneal transfer group (100% vs 55.36%, P=0000). The expression level of CXCR4 and MMP-9 were closely correlated with histological cellular differentiation, invasion depth (P=0.000, 0.001, 0.002, 0.013), and the positive expression of CXCR4 was consistent with the positive expression of MMP-9 (r=0406,P=0.000). ConclusionExpressions of CXCR4 and MMP-9 are closely related to the degree of malignancy of gastric cancer, which may provide an evidence for diagnosis and assessment of prognosis in gastric cancer. |
| keywords:Gastric cancer CXCR 4 MMP-9 Clinicopathological factors |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
