| 胃食管反流食管外症状的治疗研究 |
| 投稿时间：2011-06-03 修订日期：2011-06-29 点此下载全文 |
| 引用本文：金忠海,楼放毅,楼正才,吴小洪,陈华英,应光荣.胃食管反流食管外症状的治疗研究[J].医学研究杂志,2012,41(3):68-70 |
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| 基金项目:2010年义乌市科技基金资助项目 |
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| 中文摘要:目的探讨胃食管反流食管外症状的诊断及治疗。方法218例伴食管外症状的GERD患者随机分为3组，给予莫沙必利+奥美拉唑20mg每日1次（A组）、奥美拉唑20mg每日1次（B组）及莫沙必利+奥美拉唑20mg每日1次（C组）治疗。观察治疗6个月的症状及体征情况。结果B组与A、C两组症状有效率及痊愈率差异显著（P＜0.05）；然而，A组与C组无显著差异（P＞0.05），但C组显示比A组高18%的痊愈率。此外，B组与A、C两组体征有效率无显著差异（P＞0.05）。但C组与A、B两组痊愈率差异显著（P＜0.05）。结论双倍剂量质子泵抑制剂+莫沙必利可有效控制胃食管反流食管外症状。 |
| 中文关键词:胃食管反流 咽部异常感觉 莫沙必利 质子泵抑制剂 |
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| Treatment of Extraesophageal Sympotoms in Patients with Gastroesophageal Reflux |
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| Abstract:ObjectiveTo discuss the diagnosis and treatment of extraesophageal sympotoms in patients with gastroesophageal reflux.MethodsA total of 218 patients with extraesophageal sympotoms were distributed into three groups:mosapride plus omeprazole 20mg/d(A group), omeprazole 20mg/d(B group) and mosapride plus omeprazole 20mg/d (C group).The signs and sympotoms were estimated after fowlling-up 6 months.ResultsThe difference was statistically significant （P＜0.05）between A groups and B groups with regard to effective rate or cure rate for sympotom. The defference was statistically significant （P＜0.05）between C groups and B groups with regard to effective rate or cure rate for sympotom.However,the defference was not statistically significant (P＞0.05) between A groups and C groups,but the cure rate of C groups was 18%high than that in the A groups.In addition，the difference was not statistically significant (P＞0.05) between B groups and A groups with regard to effective rate for sign. The difference was not statistically significant (P＞0.05) between B groups and C groups with regard to effective rate for sign.However,the difference was statistically significant between B groups and C groups with regard to cure rate （P＜0.05）.ConclusionWe suggest that mosapride plus double dose proton pump inhibitor may prove to be an effective method for treating extraesophageal sympotoms in patients with gastroesophageal reflux. |
| keywords:Gastroesophageal reflux Globus sensation Mosapride Proton pump inhibitors |
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