| Expression and Significance of Plasminogen Activator Inhibitor in Osteoarthritis Synovial Membrane |
| 投稿时间：2011-06-24 修订日期：2011-07-08 点此下载全文 |
| 引用本文：李茂强,朱六龙,边振宇,季成,陆凯.Expression and Significance of Plasminogen Activator Inhibitor in Osteoarthritis Synovial Membrane[J].医学研究杂志,2012,41(3):125-127 |
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| 中文摘要:目的探讨两种纤溶酶原激活物抑制因子（PAI）在骨关节炎的发生发展中的意义。方法采用免疫组化方法检测滑膜组织中尿激酶型纤溶酶原激活物（uPA）, 组织型纤溶酶原激活物（tPA）, PAI-1, PAI-2的表达。结果骨关节炎滑膜中PAI-1, PAI-2的阳性表达比例高于正常滑膜（P<0.05）,骨关节炎滑膜中 PAI-1与uPA、tPA蛋白表达阳性细胞百分比呈直线正相关关系。结论PAI可能与骨关节炎软骨退变表现为长期慢性过程有关。 |
| 中文关键词:骨关节炎 滑膜 纤溶酶原激活物抑制因子 |
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| Abstract:ObjectiveTo investigate the significance of plasminogen activator inhibitor （PAI）in genesis and development of osteoarthritis（OA）. MethodsImmunohistochemical analysis technique was used to detect the expression of uPA,tPA and PAI in synovial tissues in 40 OA patients and 10 normal indivediuls. ResultsCompared with the control group,the ratio of PAI-1, PAI-2 positive staining increased in the OA group.There was a positive correlation between PAI-1 and uPA,PAI-1 and tPA positive staining cell percent in osteoarthritis synovial membrane.ConclusionThe PAI may play an important role in the chronic process of degradation of cartilage extracellular matrices of OA. |
| keywords:Osteoarthritis Synovial membrane PAI |
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