| 吸烟对氯吡格雷抗血小板活化作用的影响 |
| 投稿时间：2011-04-13 修订日期：2011-05-03 点此下载全文 |
| 引用本文：徐鹏,王宁夫,周亮,叶显华,童国新,冷建杭.吸烟对氯吡格雷抗血小板活化作用的影响[J].医学研究杂志,2012,41(3):127-130 |
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| 中文摘要:目的验证吸烟能否使冠心病患者冠状动脉介入治疗（PCI）术后近期氯吡格雷抗血小板活化的作用增强。方法入选择期行冠脉造影并成功行冠脉介入治疗（PCI）的不稳定心绞痛患者42例，分为吸烟组（22例）和非戒烟组（20例）。各组入院后均给予氯吡格雷300mg顿服，术后继续每日给予氯吡格雷75mg口服。服药前以流式细胞仪测定各组CD61、CD62p的阳性表达率；术后24、72h再次测定CD61、CD62p的阳性表达率。结果PCI术后24h两组的CD61、CD62p表达较术前无显著变化（CD61: -1.16%±19.06% vs -0.98%±22.19%, P=0.36；CD62p: -1.93%±10.80% vs -2.07%±15.49%,P=0.96）；PCI术后72h吸烟组CD61、CD62p表达较术前有下降趋势，而非吸烟组无下降趋势（CD61: -2.19%±21.72% vs 5.27%±2658%,P=0.46；CD62p：-6.13%±18.74% vs 0.12%±12.78%，P=0.25），但是这些差异无统计学意义。结论吸烟未增强冠心病患者PCI术后近期氯吡格雷的抗血小板活化作用。本实验未能验证吸烟能增强冠心病患者PCI术后近期氯吡格雷的抗血小板活化作用这一结论。 |
| 中文关键词:吸烟 冠心病 活化血小板 氯吡格雷 |
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| Impact of on Clopidogrel Against Platelet Activation |
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| Abstract:ObjectiveTo confirm if cigeratte smoke could enhance the role of clopidogrel against platelet activation in early post-PCI patients.MethodsTotally 42 patients with unstable coronary artery disease undergoing elective coronary angiography and successful intervention (PCI), were selected, and divided into smoking group (22 cases) and non-smoking cessation group (20 cases). Each group as given 300mg clopidogrel at once after admission and followed with 75mg daily.CD61, CD62p positive rate of expression were determinated by flow cytometry before the medication and re-determinated after 24, 72h of PCI. ResultsThe changes of CD61, CD62p expression in both groups after 24h PCI had no significant difference（CD61: -1.16%±19.06% vs -0.98%±22.19%,P=0.36；CD62p:-1.93%±10.80% vs -2.07%± 15.49%,P=0.96）. In smoking group 72h after PCI, CD61, CD62p expression was still lower than before, while the non-smoking group had no longer the performance（CD61: -2.19%±21.72% vs 5.27%±26.58%,P=0.46；CD62p：-613%±18.74% vs 0.12%±12.78%，P=0.25）, but these differences were not statistically significant.ConclusionSmoking doesn′t significantly increase the antiplatelet of clopidogrel in early post-PCI. This study failed to verify the conclusion that smoking could increase the antiplatelet of clopidogrel in early post-PCI. |
| keywords:Smoking Coronary heartdisease Activated platelet Clopidogrel |
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