| 三叶青提取物联合介入治疗兔VX2肝癌模型多层螺旋CT表现及肝功能动态分析 |
| 投稿时间：2011-07-28 修订日期：2011-08-30 点此下载全文 |
| 引用本文：贾玉柱,劳群,祁克信,陆海华,杨光钊,魏克民.三叶青提取物联合介入治疗兔VX2肝癌模型多层螺旋CT表现及肝功能动态分析[J].医学研究杂志,2012,41(4):56-58 |
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| 基金项目:浙江省中医药管理局基金资助课题（2009CB024） |
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| 中文摘要:目的评价单纯介入治疗与三叶青提取物联合介入治疗兔VX2肝移植瘤的疗效。方法33只荷瘤兔，随机分为空白对照组、单纯介入治疗组和三叶青提取物联合介入治疗组，14天后，对比分析其多层螺旋CT（MSCT）影像学改变及肝功能变化。结果三叶青提取物联合介入治疗在2周后MSCT检查显示肿瘤大小，肿瘤生长率、坏死率较单纯介入治疗及空白对照组疗效有统计学意义(P<0.05)；在肝功能方面三叶青提取物联合介入治疗组GPT、GOT明显较其他两组降低，比较有统计学意义（P<0.05）。结论三叶青联合介入对VX2兔肝癌模型的介入治疗对肿瘤抑制及兔肝功能改变有一定疗效。 |
| 中文关键词:VX2肝癌 三叶青 多层螺旋CT 肝功能 |
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| Dynamic Analysis of Manifestation of the Multi-slice CT (MSCT) and Liver Function in Interventional Treatment of Rabbit VX2 Liver Cancer Model Combined with Tetrastigma Hemsleyanum Diels et.Gilg(SYQ) Extract |
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| Abstract:ObjectiveTo evaluate the effects of the interventional treatment combined with Tetrastigma hemsleyanum Diels et.Gilg(SYQ) extract on rabbit VX2 liver tumor.MethodsTotally 33 tumor-bearing rabbits were randomly divided into 3 groups:control group, simple intervention group and intervention combined with SYQ extracts group. After 14 days, a comparative study of imaging changes of the multi-slice CT (MSCT) and liver function changes was carried out. ResultsAfter 14 days, imaging changes in the multi-slice CT (MSCT) showed that there was a significant effect in the tumor size, tumor growth rate, and necrosis rate by intervention combined with SYQ extracts group as compared with other two groups（P<0.05）.In intervention combined with SYQ extracts group, the positive rates of liver GPT, GOT were significantly lower than other two groups（P<0.05）.ConclusionInterventional treatment combined with SYQ extracts has a certain effect in inhibiting the VX2 rabbit liver tumor and maintaining a protective change in liver function. |
| keywords:VX2 liver tumor SYQ MSCT Liver function |
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