| 脂联素基因多态性与2型糖尿病肾病的关系 |
| 投稿时间：2011-07-13 修订日期：2011-08-23 点此下载全文 |
| 引用本文：彭春玲,洪郁芝,傅莉萍.脂联素基因多态性与2型糖尿病肾病的关系[J].医学研究杂志,2012,41(4):156-159 |
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| 中文摘要:目的研究脂联素（APN）基因+45位点与+276位点单核苷酸多态性（SNP）与中国浙江地区汉族人群2型糖尿病肾病(DN)的关系。方法根据尿白蛋白排泄率(UAER) 将82 例2 型糖尿病患者分成糖尿病正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组；用直接测序法分析SNP+45和+276两位点基因型和等位基因频率，并分析与其他指标的关系。结果脂联素基因SNP+45和+276两多态性位点的基因型和等位基因频率分别在正常白蛋白尿组、微量白蛋白尿组和大量白蛋白尿组3组间无统计学差异（P>0.05）。结论脂联素基因SNP+45T/G和SNP+276G/T与浙江地区汉族人群中2型糖尿病肾病无相关性。这两位点的基因多态性不能预测2型糖尿病肾病的易感性。 |
| 中文关键词:脂联素 单核苷酸多态性 糖尿病肾病 |
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| Association of Adiponectin Gene Polymorphism in Type 2 Diabetes with Nephropathy |
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| Abstract:ObjectiveTo investigate the association of single nucleotide polymorphism(SNP) of +45 and +276 loci of adiponectin（APN）gene with type 2 diabetic nephropathy (DN) in Han ethnicity population, Zhejiang province in China.MethodsEighty-two type 2 diabetic patients were assigned to normal albuminuria group, micro-albuminuria group,and macro-albuminuria group according to the urine albumin excretion rate ( UAER).Direct sequencing was used to analyze allele and genotype frequencies of SNP+45 and +276 loci, and analying the relationship with other observed indicators. ResultsThe distributions of genotype and allele frequencies of SNP+45 and +276 had no difference among three subgroups（P>0.05）.ConclusionThe T→G polymorphism of SNP+45 and G→T polymorphism of SNP+276 in adiponectin gene are not associated with type 2 diabetic nephropathy in Han ethnicity population, Zhejiang province in China.The gene polymorphisms of these two loci can not predict the susceptibility to type 2 diabetic nephropathy. |
| keywords:Adiponectin Single nucleotide polymorphisms Diabetic nephropathy |
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