| 血清GPC3联合AFP检测在HCC中的临床意义 |
| 投稿时间：2011-06-06 修订日期：2011-06-27 点此下载全文 |
| 引用本文：王攀,万卫昌,李招云.血清GPC3联合AFP检测在HCC中的临床意义[J].医学研究杂志,2012,41(5):59-61 |
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| 基金项目:浙江省医药科技基金资助项目（2006A122） |
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| 中文摘要:目的探讨血清磷脂酰肌醇蛋白聚糖3(GPC3)和甲胎蛋白（AFP）在肝细胞癌(HCC)患者中的临床意义。方法采用ELISA法检测血清GPC3和血清AFP，分析72例HCC患者、58例肝良性病变组和40例健康组血清GPC3和AFP水平。结果HCC患者血清GPC3和AFP水平显著高于肝良性病变组和健康组(P<0.05)；肝良性病变组和健康组中表达无统计学意义(P>0.05)。两者表达与肿瘤大小、是否侵袭和病理分级有关（P<0.05）；年龄、性别、有无HbsAg感染和包膜与两者表达无关（P>0.05）。单项检测灵敏度、准确度较低；联合检测灵敏度达84.7%，准确度达90.1%；两者在HCC中表达未存在直接关联（P>0.05）。结论联合检测血清GPC3和AFP水平有助于HCC的早期临床诊断。 |
| 中文关键词:肝细胞癌 磷脂酰肌醇蛋白聚糖3(GPC3) AFP |
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| Clinical Significance of Serum GPC3 and AFP in Patients with Hepatocellular Carcinoma |
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| Abstract:ObjectiveTo explore the value of serum glypican-3(GPC3) and alpha-fetoprotein(AFP) in patiens with hepatocellular carcinoma(HCC)．MethodsELISA was employed to detect serum GPC3 levels. Serum AFP levels from patients serum with HCC (n=72),nonHCC tumor samples (n=58) and controls(n=40) were measured with chemilumiescense immuniassay.ResultsThe levels of GPC3 and AFP were significantly higher in HCC than nonHCC tumor samples and controls(P<0.05).The levels were not much different from those in nonHCC tumor samples and controls(P>0.05).The levels of GPC3 and AFP seemed to be correlated with tumor diameter，the stage (by TNM classification)of HCC and/or distant metastasis(P<0.05). With combined detection of GPC3 and AFP,the sensitivity would be 84.7%, accuracy would be 90.1%.Moreover,there was no correlation between the levels of GPC3 and AFP．ConclusionDetected the expression of GPC3 and AFP are usefulness for diagnosis of primary HCC. |
| keywords:Hepatocellular carcinoma Glypican-3(GPC3) AFP |
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