| AQP1和AQP3在子痫前期患者胎盘和胎膜上的表达及意义 |
| 投稿时间：2011-07-13 修订日期：2011-08-23 点此下载全文 |
| 引用本文：陈利琼,安慧敏,朱雪琼,翁秀琴,池银归,夏康.AQP1和AQP3在子痫前期患者胎盘和胎膜上的表达及意义[J].医学研究杂志,2012,41(5):94-96 |
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| 基金项目:瑞安市科技局基金资助项目（201002049） |
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| 中文摘要:目的研究AQP1和AQP3在子痫前期患者胎盘和胎膜上的表达及其与临床资料之间的相关性，探讨其在子痫前期发病中的作用。方法选取2009年3月~2010年3月笔者医院产科收住的孕妇60例，其中子痫前期轻度组20例（实验组1），子痫前期重度组20例（实验组2），正常足月妊娠孕妇20例（对照组）。采用免疫组化SP法，检测两组胎盘、胎膜组织中AQP1和AQP3的分布及表达，同时分析其与24h尿蛋白定量、羊水量、胎儿出生体重等临床资料之间的相关性。结果AQP1、AQP3在子痫前期组胎盘上的表达较正常妊娠组上调。AQP1、AQP3在子痫前期组羊膜组织上的表达强度弱于对照组。子痫前期组患者胎盘上的AQP1、AQP3表达强度越强，其24h尿蛋白定量越高，呈线性相关。子痫前期组胎盘上的AQP1、AQP3表达强度与胎儿出生体重不呈线性相关。子痫前期组羊膜上的AQP1、AQP3表达强度与羊水量不呈线性相关。结论子痫前期组胎盘上AQP1、AQP3的表达较正常妊娠组明显上调，且与24h尿蛋白定量呈线性相关，提示胎盘组织中AQP1、AQP3表达与子痫前期疾病发生发展及病情轻重程度有关。 |
| 中文关键词:子痫前期 水通道蛋白1 水通道蛋白3 24h尿蛋白定量 |
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| Expression and Role of Aquaporin 1and Aquaporin 3 in Placenta and Fetal Membranes with Preeclampsia |
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| Abstract:ObjectiveTo study the expression of aquaporin 1(AQP1) and aquaporin 3(AQP3) in placenta and fetal membranes in pregnant women with preeclampsia,and observe their clinical data, in order to explore the pathogenesis of preeclampsia.MethodsFrom march 2009 to march 2010, 60 patients who had elective cesarean deliveries within Ruian people′s hospital were studied,of whom 20 cases of mild preeclampsia and 20 cases of severe preeclampsia were studied for experimental group and 20 women with normal term pregnancy for control group. Immunohistochemistry was used to determine expression and localization of aquaporion 1 and aquaporion 3 in placenta and fetal membranes. Meanwhile, we analyzed their relevance with 24 hours urine protein, amniotic fluid and birth weight. ResultsIn comparison to the normal pregnancies, there was increasing expression of AQP1 and AQP3 in placenta with preeclampsia.The expression of AQP1 and AQP3 in amnion with preeclampsia was down-regulated compared with that in normal pregnancies. The more expressions of AQP1 and AQP3 in placenta with preeclampsia, the more twenty-four hours urine protein sets up. They was linear dependence. There was no linear dependence between birth weight and the expressions of AQP1 and AQP3 in placenta. There was no linear dependence between amniotic fluid and the expression of AQP1 and AQP3 in amnion.ConclusionThe expression of AQP1 and AQP3 in placenta with preeclampsia is up-regulated and has linear dependence with twenty-four hours urine protein. This may prompt the relationship between the expressions of AQP1 and AQP3 in placenta and development, progress and degree of preeclmpsia. |
| keywords:Preeclampsia Aquaporin 1 Aquaporin 3 Twenty-four hours urine protein |
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