| 心肌梗死对C57BL/6J小鼠跑轮运动日节律的影响 |
| 投稿时间：2014-03-26 修订日期：2014-06-10 点此下载全文 |
| 引用本文：周岚,曹济民.心肌梗死对C57BL/6J小鼠跑轮运动日节律的影响[J].医学研究杂志,2015,44(1):36-39 |
| DOI：
10.3969/j.issn.1673-548X.2015.01.011 |
| 摘要点击次数: 1560 |
| 全文下载次数: 1166 |
|
| 基金项目:国家自然科学基金资助项目(81071072) |
|
| 中文摘要:目的 心脏活动的昼夜变化受生物钟中枢视交叉上核(SCN)调控,因而反映心脏活动的生理指标(如血压、心率、心排出量)乃至心源性猝死事件呈现明显的昼夜节律。反过来,心脏疾病也可能影响SCN的昼夜节律振荡。本研究旨在探讨心肌梗死对SCN日节律的影响。方法 通过经腹腔横膈膜液氮冷冻致局部心肌坏死的方法模拟小鼠心肌梗死,利用Mini Mitter 跑轮活动监测系统实时监测C57BL/6J小鼠心肌梗死前后跑轮运动节律的改变。结果 心肌梗死后小鼠的运动周期由23.76±0.27h缩短到23.21±0.15h,但运动活性改变不明显。结论 心肌梗死使C57BL/6J小鼠的跑轮运动日节律周期缩短,推测心肌梗死可能重调中枢SCN的周期振荡。 |
| 中文关键词:心肌梗死 昼夜节律 跑轮运动 |
| |
| Influence of Myocardial Infarction on the Circadian Rhythm of Locomotor Activities in C57BL/6J Mouse |
|
|
| Abstract:Objective The circadian variation of cardiac activity is controlled by the suprachiasmatic nucleus (SCN), and thus parameters reflecting cardiac activities (such as blood pressure, heart rate, cardiac output) and even cardiac events show obvious circadian oscillations. On the other hand, cardiac diseases may also affect the circadian rhythm. This study aimed to test the hypothesis that myocardial infarction (MI) affects the SCN-controlled circadian locomotor activities. Methods Myocardial necrotic injury was created by focal cold shock with liquid nitrogen across the intact diaphragm to mimic MI in C57BL/6J mice. Circadian wheel-running activities were continuously monitored by the Vitalview data acquisition system before and after MI. Results MI shortened the period length of circadian locomotor activities (before MI 23.76±0.27h; after MI 23.21±0.15h,P<0.05). However, the activity intensities were not significantly affected by MI. Conclusion MI shortens the period length of the circadian rhythm, but did not significantly affect the activity intensity, in C57BL/6J mice. The study suggests that MI affects the circadian oscillation of the central clock SCN. |
| keywords:Myocardial infarction Circadian rhythm Running-wheel activity |
| 查看全文 查看/发表评论 下载PDF阅读器 |
