预先静脉滴注硫酸镁及罗库溴铵对快速顺序插管过程的影响
投稿时间:2014-06-25  修订日期:2014-07-09  点此下载全文
引用本文:梁小丽,刘天婕,张益.预先静脉滴注硫酸镁及罗库溴铵对快速顺序插管过程的影响[J].医学研究杂志,2015,44(1):110-112
DOI: 10.3969/j.issn.1673-548X.2015.01.032
摘要点击次数: 969
全文下载次数: 1202
作者单位E-mail
梁小丽 563000 遵义医学院麻醉学系、麻醉与器官保护基础研究重点实验室  
刘天婕 563000 遵义医学院肾病风湿科  
张益 563000 遵义医学院麻醉学系、麻醉与器官保护基础研究重点实验室 cherishher1998@126.com 
中文摘要:目的 评价预先静脉滴注(简称:预注)硫酸镁及小剂量罗库溴铵对快速顺序插管过程的影响。方法 选择84例ASAⅠ~Ⅱ级择期全身麻醉患者,随机分为3组:A组麻醉前预注50mg/kg硫酸镁,诱导时给予0.6mg/kg罗库溴铵;B组预注等量硫酸镁,且在诱导前预注0.06mg/kg罗库溴铵,诱导时再给予0.54mg/kg的余量;C组为对照组,每组28例。记录各组的起效时间、阻断时间、插管条件以及插管过程中的平均动脉压和心率变化。结果 起效时间:B组P<0.05);A、B组阻断时间明显长于C组(P<0.01),且插管条件也显著优于C组(P<0.05)。插管后即刻A、B组的平均动脉压显著低于C组(P<0.01)。结论 预注硫酸镁和小剂量的罗库溴铵作为快速诱导插管的辅助方法,可使整个过程更加高效、平稳,值得进一步推广。
中文关键词:硫酸镁  罗库溴铵  快速顺序插管  预注法
 
Effect of Magnesium Sulphate and Rocuronium Priming on Rapid Sequence Intubation
Abstract:Objective To investigate the effect of magnesium sulphate pre-treatment and rocuronium priming on rapid sequence intubation (RSI). Methods Eighty fowr patients with ASA Ⅰ-Ⅱ, who have undergone elective surgery under general anesthesia, were randomly assigned into three groups with 28 cases in each group. Patients in group A were administrated 50mg/kg magnesium sulphate before anesthesia and 0.6mg/kg rocuronium for induction. Equivalent magnesium sulphate was given to patient in group B and 0.06mg/kg rocuronium was administrated 3min before a further dose of 0.54mg/kg rocuronium. Group C was control group. The time from the last injection of rocuronium to 100% depression of the single twitch (onset time) and return of adequate neuromuscular transmission as measured by train-of-four equal to two (duration of blockade), tracheal intubation condition and the changes of MAP and HR during the process of intubation were measured. Results Onset time was as fllowing of group B (87.9±12.7s)P<0.05); Blockade duration in group A and B were (42.0±5.6)s and (40.6±6.0)s, which was significantly longer than group C (32.6±6.1s)(P<0.01).Tracheal intubation condition of patients in group A and B was significantly better than group C (P<0.05). Compared with group C, significant reduction in MAP and HR was observed in group A and B after intubation instantly (87.2±7.1mmHg and 87.7±5.9mmHg vs 95.5±9.1mmHg,P<0.01). Conclusion As an auxiliary method for rapid sequence intubation, magnesium sulphate pre-treatment and rocuronium priming can accelerate and smooth the whole process, which deserve to be further developed and popularized.
keywords:Magnesium sulphate  Rocuronium  Rapid sequence intubation  Priming principle
查看全文  查看/发表评论  下载PDF阅读器

京公网安备 11010502037822号