丹参川芎嗪注射液对急性胰腺炎临床疗效的影响
投稿时间:2014-06-07  修订日期:2014-06-25  点此下载全文
引用本文:龚建娥,方云斌,汤维新.丹参川芎嗪注射液对急性胰腺炎临床疗效的影响[J].医学研究杂志,2015,44(1):136-138
DOI: 10.3969/j.issn.1673-548X.2015.01.040
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作者单位
龚建娥 321300 浙江省兰溪市人民医院内科 
方云斌 321300 浙江省兰溪市人民医院内科 
汤维新 321300 浙江省兰溪市人民医院内科 
中文摘要:目的 观察丹参川芎嗪注射液对急性胰腺炎的临床疗效,探讨其对NF-κB炎性反应通路的影响。方法 收集2012年6月~2014年2月兰溪市人民医院收治的急性胰腺炎患者68例,68例患者随机分为常规治疗对照组和丹参川芎嗪注射液治疗观察组,每组34例。另取笔者医院健康体检者30例作为正常对照。P65、IL-6、TNF-α表达的检测使用ELISA法。结果 治疗前观察组和对照组P65、IL-6、TNF-α蛋白表达水平差异无统计学意义(P>0.05),但均显著高于正常对照组(P<0.01),治疗后两组P65、IL-6、TNF-α表达均出现显著减低(P<0.05和P<0.01),但治疗后观察组减低的幅度显著高于对照组(P<0.05)。观察组的血淀粉酶恢复正常时间、腹痛缓解时间、平均住院时间分别为5.16±1.64、3.34±0.93和9.38±2.56天,均显著低于对照组的8.12±2.52、4.43±1.21和12.64±3.61天(P<0.05)。观察组临床治疗有效率为91.2%显著优于对照组的79.4%。观察组并发性发生率为32.4%显著低于对照组的55.9%(P<0.05)。结论 丹参川芎嗪可以抑制NF-κB信号通路减低急性胰腺炎患者的炎性反应,临床疗效显著,值得临床借鉴采用。
中文关键词:丹参川芎嗪  急性胰腺炎  NF-κB通路
 
Clinical Efficacy of Danshen Chuanxiongqin Injection on Patients with Acute Pancreatitis
Abstract:Objective To detect the clinical efficacy of Danshen Chuanxiongqin injection on patients with acute pancreatitis (AP) and explore its effect on NF-κB pathway. Methods A total of 68 patients with AP were enrolled in this study. All the patients were divided into control group(n=34) and Danshen Chuanxiongqin injection treatment observation group(n=34). Another 30 cases of healthy person were used as normal control. The expression of P65, IL-6, and TNF-α was detected by ELISA analysis. Results Before treatment, the expression of P65, IL-6, and TNF-α were of no significant difference between control and observation group (P>0.05), which were all significant lower than those in healthy control group (P<0.01). After treatment, P65, IL-6 and TNF-α expression were significantly decreased in the two groups (P<0.05 and P<0.01). The blood amylase returned to normal time, abdominal pain relief time, the average hospital stay in observation group were 5.16±1.64days, 3.34±0.93days and 9.38±2.56days, which were significantly lower than those of 8.12±2.52days, 4.43±1.21days and 12.64±3.61days in control group(P<0.05). The clinic effective rate in observation was 91.2%, which was higher than that of 79.4% in control group (P<0.05). The complication rate in observation was 32.4%, which was higher than that of 55.9% in control group (P<0.05). Conclusion Danshen Chuanxiongqin can inhibit NF-κ B pathway to decrease inflammatory reaction in patients with acute pancreatitis, which showed significantly clinical effect, with worthy of clinical application.
keywords:Danshen chuanxiongqin  Acute pancreatitis  NF-κB pathway
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