| 生长激素释放肽-6对大鼠心率昼夜节律的影响 |
| 投稿时间：2014-03-26 修订日期：2014-06-10 点此下载全文 |
| 引用本文：周岚,曹济民.生长激素释放肽-6对大鼠心率昼夜节律的影响[J].医学研究杂志,2015,44(2):32-35 |
| DOI：
10.3969/j.issn.1673-548X.2015.02.009 |
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| 基金项目:国家自然科学基金资助项目(81071072) |
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| 中文摘要:目的 探讨GHRP-6对心率昼夜节律的影响。方法 给大鼠在体植入E-Mitter传感器, 实时监测心率, 观察GHRP-6对大鼠心率昼夜节律的影响。结果 作为昼伏夜出动物, Wistar大鼠正常时夜间的心率较白天快。GHRP-6(100μg/kg)可使大鼠夜间心率显著减慢, 而对白天的心率影响不大, 导致心率的昼夜节律性降低。结论 GHRP-6使大鼠心率变化的日节律明显减弱, 因此GHS-R信号通路可能对心脏活动日节律有调节作用。 |
| 中文关键词:GHRP-6 昼夜节律 心率 |
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| Effect of GHRP-6 on the Circadian Rhythm of Heart Rate in Wistar Rats |
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| Abstract:Objective To investigate the effect of GHRP-6 on the circadian rhythm of heart rate. Methods E-Mitter, a heart rate (HR) sensor, was implanted subcutaneously by surgery in Wistar rats. Continuous real-time monitoring of HR was performed. Results As nocturnal animals, rats showed faster HR at night than during the day. GHRP-6 (100μg/kg) significantly decreased the HR at night, but did not significantly affect the HR in the day time. Therefore, GHRP-6 decreased the circadian variation of HR in this species. Conclusion GHRP-6 blunted the circadian oscillation of HR in Wistar rats, suggesting a role of GHSR in the regulation of cardiac activities. |
| keywords:GHRP-6 Circadian rhythm Heart rate |
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