依托考昔治疗急性重度痛风性关节炎的疗效及影响因素
投稿时间:2014-06-26  修订日期:2014-07-28  点此下载全文
引用本文:徐玲玲,李琳娜,薛耀明.依托考昔治疗急性重度痛风性关节炎的疗效及影响因素[J].医学研究杂志,2015,44(2):108-112
DOI: 10.3969/j.issn.1673-548X.2015.02.030
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作者单位E-mail
徐玲玲 510515 广州, 南方医科大学南方医院内分泌代谢科 lucylingl@126.com 
李琳娜 510515 广州, 南方医科大学南方医院内分泌代谢科  
薛耀明 510515 广州, 南方医科大学南方医院内分泌代谢科  
中文摘要:目的 分析口服依托考昔治疗急性重度痛风性关节炎的疗效及影响因素, 指导临床优化治疗方案。方法 2011年1月~2013年12月来自笔者医院内分泌科确诊的急性重度痛风性关节炎94例, 疼痛发作在72h之内, 均为男性, 患者年龄20~78岁, 平均年龄45.1±14.3岁, 予每天口服依托考昔120mg, 连服4天, 于治疗第4天比较治疗前后关节疼痛、肿胀、皮肤发红的变化, 以每天服药后的第4h为观察点, 采用Likert量表法对关节症状进行评价, 并对疗效的影响因素进行分析。结果 急性重度痛风性关节炎经依托考昔治疗后可有效减轻疼痛, 减轻关节肿胀, 减轻皮肤发红 (P<0.05);病程长, 体重指数(BMI)水平高, 尿酸水平高, 发作频率高, 则疗效越差(P<0.05);发作时间越短, 疗效越好(P<0.05);受累关节在第1跖趾关节的疗效好(P<0.05) 。结论 依托考昔120mg 1次/天, 持续4天可显著改善急性重度痛风性关节炎患者的疼痛和炎性症状, 在控制体重、降低尿酸的基础上, 尽早治疗可能疗效更好。
中文关键词:急性痛风性关节炎  依托考昔  影响因素
 
Clinical Effects and Influence Factors of Severe Acute Gouty Arthritis Treated by Etoricoxib
Abstract:Objective To evaluate the efficacy and influence factors of severe acute gouty arthritis treated by Etoricoxib. Methods During the period of January 2011 to December 2013, totally 94 patients diagnosed of severe acute gouty arthritis in the department of Endocrinology in Nanfang hospital were enrolled. The patients were aged 20-78 (mean 45.1±14.3) and all the cases were male, with pain attacking within 72 hours. Etoricoxib 120mg qd was taken orally for four days, and the changes of pain, swelling and redness of the joint were assessed before and after treatment. The fourth hour after taking drug everyday was defined as the observation point and a Likert scale was used for evaluating the joint symptom. The factors that affecting the efficacy of treatment were also analyzed. Results Etoricoxib treatment effectively relieved joint pain, swelling and skin redness in patients with severe acute gouty arthritis (all P<0.05). The efficacy of treatment is negatively correlated with the duration of disease, the BMI, the uric acid level and the gout attack frequency (all P<0.05). Gout attacking in the first metatarsophalangeal joint might suggest a better efficacy (P<0.05). Conclusion Etoricoxib 120mg qd for 4 days significantly released arthritis pain and inflammatory symptoms of severe acute gouty. Along with the same controlling conditions of body weight and uric acid levels, earlier treatments result the better treatment efficacy.
keywords:Acute gouty arthritis  Etoricoxib  Influencing factors
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