| 血浆IL-23、IL-17水平与慢性阻塞性肺疾病的相关性研究 |
| 投稿时间：2014-07-24 修订日期：2014-08-26 点此下载全文 |
| 引用本文：黄其钦,蒋加雁,卢成跃.血浆IL-23、IL-17水平与慢性阻塞性肺疾病的相关性研究[J].医学研究杂志,2015,44(2):123-126 |
| DOI：
10.3969/j.issn.1673-548X.2015.02.034 |
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| 中文摘要:目的 本研究旨在探讨血浆白细胞介素(IL)-23和IL-17水平与慢性阻塞性肺疾病(COPD)的关系。方法 收集75例COPD患者和80例正常对照者, 采用酶联免疫吸附法检测血浆IL-23和IL-17水平。经t检验比较血浆IL-23和IL-17水平在COPD组和对照组之间的差异, 以及其与COPD患者病程的关系。采用Pearson相关分析法检验COPD患者中血浆IL-23与IL-17水平的相关性。结果 COPD患者中血浆IL-23和IL-17的平均水平均显著高于对照组(IL-23: 751.17±155.36 vs 686.88±147.36ng/L, t=2.644, P=0.009; IL-17: 1.79±0.21 vs 1.71±0.17ng/L, t=2.614, P=0.010)。与稳定期COPD患者相比较, 急性加重期患者中血浆IL-23和IL-17的平均水平亦显著升高(IL-23: 801.31±141.69 vs 717.75±128.74ng/L, t=2.645, P=0.010; IL-17: 2.36±0.12 vs 1.41±0.16ng/L, t=27.714, P<0.001)。采用Pearson相关分析法, 结果显示, COPD患者中血浆IL-23水平与IL-17水平呈正相关(r=0.349, P=0.011)。结论 血浆IL-23和IL-17水平可能参与COPD的形成, 并能影响疾病的病程。COPD患者中血浆IL-23水平与IL-17水平密切相关。 |
| 中文关键词:慢性阻塞性肺疾病 白细胞介素-23 白细胞介素-17 |
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| Associations of Chronic Obstructive Pulmonary Disease with Plasma Levels of Interleukin-23 and Interleukin-17 |
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| Abstract:Objective To analyze the associations of chronic obstructive pulmonary disease (COPD) with plasma levels of interleukin(IL)-23 and IL-17. Methods A total of 75 COPD patients and 80 healthy controls were collected. Plasma levels of IL-23 and IL-17 were examined by enzyme-linked immunosorbent assay (ELISA). Comparison of average plasma levels of IL-23 and IL-17 between groups was performed by Student's test. Pearson correlative analysis was further conducted to evaluate the relationship between plasma levels of IL-23 and IL-17 in patients with COPD. Results The average plasma levels of IL-23 and IL-17 in COPD patients were significantly higher than in the controls (IL-23: 751.17±155.36 vs 686.88±147.36 ng/L, t=2.644, P=0.009; IL-17: 1.79±0.21 vs 1.71±0.17 ng/L, t=2.614, P=0.010). Furthermore, the average plasma levels of IL-23 and IL-17 were significantly higher in patients with acute exacerbations of COPD than in those with COPD on stable phase (IL-23: 801.31±141.69 vs 717.75±128.74 ng/L, t=2.645, P=0.010; IL-17: 2.36±0.12 vs 1.41±0.16 ng/L, t=27.714, P=0.000). By means of Pearson correlative analysis, moreover, the plasma levels of IL-23 in COPD patients were found to be positively related with the plasma levels of IL-17 (r=0.349, P=0.011). Conclusion The plasma levels of IL-23 and IL-17 may be involved in the development of COPD, and influence the course of the disease in COPD patients. Plasma levels of IL-23 in patients with COPD was closely linked to the levels of IL-17. |
| keywords:Chronic obstructive pulmonary disease Interleukin-23 Interleukin-17 |
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