| 前列地尔联合甲泼尼龙针改善血栓前状态治疗AECOPD临床分析 |
| 投稿时间：2014-06-16 修订日期：2014-06-30 点此下载全文 |
| 引用本文：叶海峰,谢海波.前列地尔联合甲泼尼龙针改善血栓前状态治疗AECOPD临床分析[J].医学研究杂志,2015,44(2):137-140 |
| DOI：
10.3969/j.issn.1673-548X.2015.02.038 |
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| 中文摘要:目的 观察前列地尔联合甲泼尼龙对AECOPD炎症以及血栓前状态的影响, 并分析其临床疗效。方法 选取2011年8月~2013年8月于舟山市妇幼保健院进行治疗的AECOPD患者100例, 随机分成甲泼尼龙治疗对照组和前列地尔联合甲泼尼龙治疗观察组, 每组50例。IL-6、TNF-α表达的检测使用ELISA法。比较两组的全血高切黏度、全血低切黏度、血浆黏度等血液流变指标, 以及临床疗效和不良反应发生率。结果 治疗前对照组和观察组全血高切黏度、全血低切黏度、血浆黏度差异无统计学意义(P>0.05)。治疗后两组均出现显著减低(P<0.05), 但观察组的减低效应显著优于对照组(P<0.05)。治疗前观察组和对照组IL-6、TNF-α表达水平差异无统计学意义(P>0.05), 治疗后IL-6和TNF-α均显著减低(P<0.05和P<0.01), 但治疗后IL-6、TNF-α表达水平在观察组显著低于对照组(P<0.05)。对照组咳嗽缓解时间、呼吸困难消失时间、啰音消失时间以及住院时间分别为5.74±1.62、3.68±0.76、5.27±1.24、9.74±2.28天, 显著长于观察组的3.76±1.03、2.53±0.58、3.36±0.88、7.22±1.69天(P<0.05)。观察组临床治疗有效率为90.0%, 显著优于对照组的76.0%(P<0.05)。结论 前列地尔联合甲泼尼龙治疗AECOPD, 可以显著改善患者的血栓前状态, 抑制炎性反应, 临床安全、有效, 值得推广使用。 |
| 中文关键词:前列地尔 甲泼尼龙 慢性阻塞性肺疾病急性加重 血栓前状态 炎性反应 |
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| Clinical Efficacy of Alprostadil and Methylprednisolone on Prethrombotic State in Patients with AECOPD |
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| Abstract:Objective To observe the effect of alprostadil and methylprednisolone on inflammation and hemorrheology in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and explore its clinical efficacy. Methods One hundred cases of AECOPD patients were enrolled in this study. All the patients were divided into: Methylprednisolone control group(n=50) and Alprostadil and Methylprednisolone observation group(n=50). The expression of IL-6, and TNF-α was detected by ELISA analysis. The high shear blood viscosity, whole blood viscosity, plasma viscosity, clinic effects and side effects were compared between the two groups. Results Before treatment, the high shear blood viscosity, whole blood viscosity, plasma viscosity had no significant difference between control and observation group (P>0.05). After treatment, They were significantly decreased in the two groups (P<0.05). However, the changes were better in observation group than that in control group (P<0.05). Before treatment, the IL-6 and TNF-α had no significant difference between control and observation group (P>0.05). After treatment, the IL-6 and TNF-α was significantly decreased in control and observation group (P<0.05 and P<0.01). However, the IL-6 and TNF-α had significant difference between control and observation group (P<0.05). The time of cough relief, disappearance of breath difficult, wheeze relief and hospital during was 5.74±1.62d, 3.68±0.76 d, 5.27±1.24 d, and 9.74±2.28 d in control group, which was longer than that of 3.76±1.03d, 2.53±0.58d, 3.36±0.88d, and 7.22±1.69d in observation group. The clinic effective rate in observation was 90.0%, which was higher than 76.0% in control group (P<0.05). Conclusion Alprostadil and methylprednisolone could significantly improve the prothrombotic state and inhibit inflammatory reaction of patients with AECOPD. And which also showed effectively clinical efficacy and safty to treat AECOPD patients. |
| keywords:Alprostadil Methylprednisolone Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) Prethrombotic state Inflammatory reaction |
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