锥形束CT配准前后的肺癌调强放疗计划的临床研究
投稿时间:2014-07-26  修订日期:2014-08-19  点此下载全文
引用本文:姚冬明.锥形束CT配准前后的肺癌调强放疗计划的临床研究[J].医学研究杂志,2015,44(2):147-149
DOI: 10.3969/j.issn.1673-548X.2015.02.041
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作者单位E-mail
姚冬明 310022 杭州, 浙江省肿瘤医院物理室 happyday0@163.com 
中文摘要:目的 比较配准前后锥形束CT的肺癌调强放疗计划。方法 选择22例肺癌患者为研究对象, 患者每周1次CBCT扫描(行治疗前、治疗后扫描), 对比校正前后各参数指标。结果 CBCT校正后的PTV体积有优势(P<0.05), 其他指标校正前后均相似(P>0.05)。CBCT校正后的双肺平均剂量有优势(P<0.05), 而脊髓最大剂量校正前后相似(P>0.05)。CBCT校正前后, 双肺V5、V10、V20、V30、V50等指标均相似(P均>0.05)。校正后NTCP随V5、V10、V20升高有降低趋势(P=0.152、0.048、0.000)。结论 经CBCT校正后的放疗计划可有效减少NTCP, 增加PTV剂量, 提高放疗效果, 且安全性较高, 可提升肺癌的治疗效果。
中文关键词:肺癌  锥形束CT  放疗  调强
 
Comparison of Intensity-modulated Radiotherapy Plan of Cone Beam CT before and after the Registration of Lung Cancer
Abstract:Objective To study intensity-modulated radiotherapy plan of cone beam CT before and after the registration of lung cancer. Methods Totally 22 patients with lung cancer were selected as the research object. Patients got CBCT scan 1 times a week (line scan before and after treatment). The parameters before and after the correction were compared. Results PTV volume had advantages of CBCT adjusted (P<0.05), and other indicators before and after correction were similar (P>0.05). Mean dose of CBCT had advantages after correction of the double lung (P<0.05), whereas the spinal cord before and after the maximum dose correction was similar (P>0.05). CBCT before and after correction, the double lung V5, V10, V20, V30, V50 and other indicators were similar (P>0.05). After correction, NTCP with increasing V5, V10, V20 had a tendency to reduce (P=0.152, 0.048, 0.000). Conclusion Radiotherapy plan after the correction of CBCT can effectively reduce NTCP, increase the PTV dose, improve the effect of radiotherapy, and has high safety, and it can improve the therapeutic effect of lung cancer.
keywords:Lung cancer  Cone beam CT  Radiation therapy  Intensity-modulated
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