| 联合应用血必净与钠洛酮干预重症胸腹损伤急性肝细胞功能损害的效果 |
| 投稿时间：2014-05-24 修订日期：2014-06-14 点此下载全文 |
| 引用本文：李志伟,郭雅琼,王文军,徐旭,董浩,代文光,王树龙,马之嘉,付芳,赵立强.联合应用血必净与钠洛酮干预重症胸腹损伤急性肝细胞功能损害的效果[J].医学研究杂志,2015,44(2):156-158,116 |
| DOI：
10.3969/j.issn.1673-548X.2015.02.044 |
| 摘要点击次数: 955 |
| 全文下载次数: 1171 |
| 作者 | 单位 | E-mail | | 李志伟 | 010051 呼和浩特, 中国人民解放军第253医院急诊科 | | | 郭雅琼 | 010051 呼和浩特, 中国人民解放军第253医院急诊科 | | | 王文军 | 010051 呼和浩特, 中国人民解放军第253医院急诊科 | | | 徐旭 | 010051 呼和浩特, 中国人民解放军第253医院急诊科 | | | 董浩 | 010051 呼和浩特, 中国人民解放军第253医院急诊科 | | | 代文光 | 010051 呼和浩特, 中国人民解放军第253医院急诊科 | | | 王树龙 | 010051 呼和浩特, 中国人民解放军第253医院急诊科 | | | 马之嘉 | 010051 呼和浩特, 中国人民解放军第253医院急诊科 | | | 付芳 | 010051 呼和浩特, 中国人民解放军第253医院急诊科 | | | 赵立强 | 010051 呼和浩特, 中国人民解放军第253医院急诊科 | ZhaoLiqiangnm@163.com |
|
|
| 中文摘要:目的 探讨联合应用血必净(XBJ)、钠洛酮(NX)干预重症胸腹损伤急性肝细胞功能损害的效果。方法 以2009年1月~2013年6月在笔者医院就诊, 创伤指数(TI)≥17分, 除外合并颅脑损伤及在急诊死亡的重症胸腹创伤患者为入选标准, 干预组112例, 对照组57例;干预组患者在就诊及入院时分别检查谷丙转氨酶(ALT)、谷草转氨酶(AST)、肿瘤坏死因子-α(TNF-α)、内毒素(LPS)、白细胞介素-6(IL-6)、磷脂酶A2(PLA2), 对照组仅于入院时进行同样项目检查。结果 干预组患者就诊时ALT为328.43±21.35U/L, AST为298.49±19.62U/L;入院时ALT为58.12±11.67U/L, AST为54.72±10.31U/L。对照组患者入院时ALT为350.88±27.72U/L, AST为302.91±24.31U/L;干预后ALT、AST降低, 与干预前及对照组相比差异有统计学意义P < 0.01。结论 联合应用XBJ与NX治疗可显著减轻重症胸腹损伤后急性肝细胞功能损害, 对减少并发症、预防多器官功能障碍综合征(MODS)有重要意义。 |
| 中文关键词:重症胸腹损伤 急性肝细胞功能损害 血必净 钠洛酮 效果 |
| |
| Intervention Effect of Xuebijing Combined with Naloxone in Hepatic Cells Insufficiency during Severe Thoracoabdominal Injuries |
|
|
| Abstract:Objective To study the intervention effect of Xuebijing combined with naloxone in hepatic cells insufficiency during severe thoracoabdominal injuries. Methods Severe thoracoabdominal injury patients with trauma index (TI)≥17 points except the ones associated craniocerebral injuries and died in emergency department were randomly divided into two groups: the intervention group (n=112) and the control group (n=57). The patients were all collected at 253th Hospital of PLA between January 2009 and June 2013.The intervention groups were tested at the time of arriving at and the time of leaving the emergency department to the inpatient department for alanine aminotransferas (ALT)、aspartate aminotransferase (AST), tumor necrosis factor-α(TNF-α), lipopolysaccharide (LPS), interleukin-6 (IL-6) and phospholipase A2 (PLA2).The control group were just tested at the time of leaving the emergency department for the same items. Results At the time of arriving at the emergency department, ALT was 328.43±21.35U/L, and AST 298.49±19.62U/L.At the time of leaving the emergency department, ALT was 58.12±11.67U/L, and AST 54.72±10.31U/L.At the the time of leaving the emergency department the records of the control group, ALT was 350.88±27.72U/L, and AST 302.91±24.31U/L.After the intervention the records of ALT and AST were significantly lower than the the time before intervention and the control group (all P < 0.01). Conclusion Xuebijing combined with naloxone can significantly improve the hepatic cells insufficiency during severe thoracoabdominal injuries which have important significance in reducing incidence rate of complication, prevent multiple organ dysfunction score (MODS). |
| keywords:Severe thoraco abdominal injuries Acute hepatic cells insufficiency Xuebijing Naloxone Intervention effect |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
