| 新疆维吾尔族男性及女性瘦素水平与代谢综合征的关系及差异 |
| 投稿时间：2014-09-01 修订日期：2014-09-17 点此下载全文 |
| 引用本文：骆秦,李南方,索菲亚·阿不力克木,毕云伟,姚晓光,洪静,常桂娟.新疆维吾尔族男性及女性瘦素水平与代谢综合征的关系及差异[J].医学研究杂志,2015,44(3):48-53 |
| DOI：
10.3969/j.issn.1673-548X.2015.03.014 |
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| 作者 | 单位 | E-mail | | 骆秦 | 830001 乌鲁木齐, 新疆自治区人民医院高血压中心 | | | 李南方 | 830001 乌鲁木齐, 新疆自治区人民医院高血压中心
830001 乌鲁木齐, 新疆高血压研究所 | lnanfang2010@sina.com | | 索菲亚·阿不力克木 | 830001 乌鲁木齐, 新疆自治区人民医院高血压中心 | | | 毕云伟 | 830001 乌鲁木齐, 新疆自治区人民医院高血压中心 | | | 姚晓光 | 830001 乌鲁木齐, 新疆自治区人民医院高血压中心
830001 乌鲁木齐, 新疆高血压研究所 | | | 洪静 | 830001 乌鲁木齐, 新疆自治区人民医院高血压中心
830001 乌鲁木齐, 新疆高血压研究所 | | | 常桂娟 | 830001 乌鲁木齐, 新疆自治区人民医院高血压中心 | |
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| 基金项目:国家自然科学基金资助项目(81160015) |
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| 中文摘要:目的 探讨新疆维吾尔族男性及女性瘦素水平与代谢综合征(MS)的关系及差异。方法 从新疆和田地区维吾尔族流行病学调查的数据库中, 随机选取781例个体, 年龄30~70岁。其中, MS组403例、对照组378例, 男性249例、女性532例。比较男性及女性在不同瘦素水平时MS的发生频率及其各组分的差异;并采用多元线性回归的方法, 分析男性及女性瘦素水平的主要影响因素。结果 新疆维吾尔族男性瘦素的中位数为0.58ng/ml, 女性瘦素的中位数为1.76ng/ml, 女性的瘦素水平约为男性的3倍(P<0.01)。男性及女性中MS组的瘦素水平均明显高于对照组(P<0.01);随着瘦素水平的递增, 男性及女性的MS分布频率、腰围(WC)、体重指数(BMI)、舒张压(DBP)、甘油三酯(TG)、胰岛素抵抗指数(HOMA-IR)均逐步升高(P<0.05)。多元线性回归分析显示, 男性的瘦素水平与LnHOMA-IR(B=0.179, P<0.05)及BMI(B=0.077, P<0.05)呈正相关;女性的血清瘦素水平与BMI呈正相关(B=0.067, P<0.001), 与年龄呈负相关(B=-0.012, P<0.01) 结论 新疆维吾尔族男性及女性中MS患者的瘦素水平均明显升高, 瘦素水平与MS的发生频率及BMI均呈正相关;但存在性别差异, 男性的瘦素水平与胰岛素抵抗呈正相关, 而女性的瘦素水平与年龄呈负相关。 |
| 中文关键词:瘦素 代谢综合征 新疆维吾尔族 男性 女性 |
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| Relationship of Leptin with Metabolic Syndrome and Differences in Male and Female of Xinjiang Uygur Population |
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| Abstract:Objective To investigate the relationship of leptin with metabolic syndrome and differences in male and female of Xinjiang Uygur Population. Methods A total of 781 individuals were selected randomly from the data base of Hetian area in Xinjiang Uygur Autonomous Region, aged from 30 to 70 years, included 403 MS subjects and 378 non-MS controls, 249 men and 532 women. We compared the frequency of MS and levels of its components in different levels of leptin in male and female, and analysed the main impact factors of leptin in male and female using multiple linear analysis. Results The median of leptin in female was 1.76ng/ml, which was approximately 3 times of male (0.58ng/ml, P<0.01). Leptin levels were higher than that of control group both in male and female (P<0.01). With the increasing levels of leptin, frequency of MS, levels of WC, body mass index (BMI), diastolic blood pressure (DBP) and triglyceride (TG) were increased in both men and women. In male, according to multiple linear analysis, levels of leptin were positively correlated with LnHOMA-IR(B=0.179, P<0.05)and BMI(B=0.077, P<0.05). In female, levels of leptin were positively correlated with BMI(B=-0.067, P<0.001)and negatively correlated with age. Conclusion Levels of leptin were significantly elevated in MS both in male and female of Xinjiang Uygur population and were positively correlated with frequency of MS and levels of BMI. But there were gender differences. Leptin levels were positively correlated with insulin resistance in male and negatively correlated with age in female. |
| keywords:Leptin Metabolic syndrome Xinjiang Uygur Population Male Female |
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