| 糖皮质激素联合盐酸氨溴索治疗分泌性中耳炎疗效的系统评价 |
| 投稿时间：2014-07-23 修订日期：2014-09-11 点此下载全文 |
| 引用本文：李智量,屈季宁.糖皮质激素联合盐酸氨溴索治疗分泌性中耳炎疗效的系统评价[J].医学研究杂志,2015,44(3):107-110 |
| DOI：
10.3969/j.issn.1673-548X.2015.03.030 |
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| 中文摘要:目的 系统评价糖皮质激素联合盐酸氨溴索治疗分泌性中耳炎的效果。方法 通过检索Medline、EMbase、中国知网(CNKI)、维普数据库(VIP)和万方数据库(Wanfang Data)等数据库, 以"secretory otitis media、exudative otitis media、non-suppurative otits media、ambroxol hydrochloride、mucosolvan、triamcinolone、dexamethasone、prednisone、curative effect"和"分泌性中耳炎、渗出性中耳炎、非化脓性中耳炎、盐酸氨溴索、沐舒坦、曲安奈德、地塞米松、泼尼松(强的松)、疗效"作为主题词检索以常规治疗组为对照组, 盐酸氨溴索为干预组治疗分泌性中耳炎的随机对照试验研究(RCT)的相关文献, 并辅以手工检索进行文献追索。对纳入文献进行严格的质量评价, 由2名研究者分别进行数据统计, 并进行Meta分析。结果 治疗组共314耳, 对照组共288耳。Meta分析结果显示, 糖皮质激素联合盐酸氨溴索治疗分泌性中耳炎的效果优于常规治疗(P<0.05), 其总有效率合并OR及其95%CI为3.23(2.16~4.82)。结论 糖皮质激素联合盐酸氨溴索应用利于分泌性中耳炎的治疗。 |
| 中文关键词:分泌性中耳炎 盐酸氨溴索 糖皮质激素 疗效 |
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| Effect of Glucocorticoids Combined with Ambroxol Hydrochloride on Secretory Otitis Media: A Meta-analysis |
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| Abstract:Objective To evaluate the effects of glucocorticoids combined with ambroxol hydrochloride on secretory otitis media. Methods Randomized, controlled trials(RCT) of glucocorticoids combined with ambroxol hydrochloride in the treatment of secretory otitis media, published in Medline, EMbase, CNKI, VIP and Wanfang Data, were collected. The methodological quality of the trials and the valid data were evaluated by Meta-analysis. Results Five RCTs were included in ths study. Meta analysis showed that the effect of the treatment group was better than the control. The general OR and 95% CI for the overall efficacy were 3.23(2.16-4.82). Conclusion Glucocorticoids combined with ambroxol hydrochloride is benefit for the treatment of secretory otitis media. |
| keywords:Secretory otitis media Ambroxol hydrochloride Glucocorticoids Effect |
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