| 抗核抗体荧光核型与狼疮肾炎病理类型的相关性分析 |
| 投稿时间：2014-04-25 修订日期：2014-05-07 点此下载全文 |
| 引用本文：严艳玲,罗雄燕,杨明辉,袁林,向阳,袁国华.抗核抗体荧光核型与狼疮肾炎病理类型的相关性分析[J].医学研究杂志,2015,44(3):155-157 |
| DOI：
10.3969/j.issn.1673-548X.2015.03.045 |
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| 中文摘要:目的 探讨抗核抗体(ANA)荧光核型与狼疮肾炎病理类型的相关性。方法 采用间接免疫荧光法测定75例行肾活检LN患者的ANA荧光核型, 并与56例无狼疮肾炎的系统性红斑狼疮患者对照, 分析ANA荧光核型与狼疮肾炎病理改变的关系。结果 75例狼疮肾炎患者病理类型分属Ⅰ~Ⅵ型者有12例(16.0%)、38例(50.7%)、3例(4.0%)、9例(12.0%)、12例(16.0%)和1例(1.3%)。75例狼疮肾炎患者ANA均为阳性, 56例无狼疮肾炎患者中54例(96%)ANA阳性。在38例Ⅱ型狼疮肾炎患者中均质型ANA占16(42.1%), 明显高于无狼疮肾炎患者的23.2%(P<0.05)。而在12例Ⅴ型狼疮肾炎中, 11例(91.7%)ANA荧光核型为颗粒型或颗粒型/均质型, 明显高于无狼疮肾炎患者的51.8% (P<0.05) 。结论 均质型ANA与Ⅱ型LN发病有关, 而颗粒型或颗粒型+均质型ANA则可能在Ⅴ型LN病变中发挥作用。 |
| 中文关键词:系统性红斑狼疮 狼疮肾炎 抗核抗体 荧光核型 |
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| Association Study of Antinuclear Antibody Patterns with Histological Types of Lupus Nephritis |
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| Abstract:Objective To analysis the association between immunifluorescence patterns of antinuclear antibody (ANA) and the histological changes in lupus nephritis(LN). Methods Immunifluorescence patterns of ANA were detected in 75 patients with LN underwent renal biopsy and compared 56 patients without LN by using indirect immunifluorescence assay (IFA). Histological type of LN was classed according to the modified World Health Organization (WHO) classification, and the association of ANA patterns with histological types of LN was then analyzed. Results Among 75 patients with LN, the WHO classⅠ-Ⅵ LN was identified in 12(16.0%), 38 (50.7%), 3 (4.0%), 9 (12.0%), 12 (16.0%) and 1 (1.3%) patients respectively. 75 patients with lupus nephritis ANA were all positive, and 56 cases of patients with lupus nephritis had 54 cases of ANA positive.In 38 cases of Ⅱ patients with lupus nephritis type homogeneous ANA accounted for 16 (42.1%), which was significantly higher than the 23.2% of the patients without lupus nephritis (P<0.05).In 12 cases of type Ⅴ lupus nephritis, 11 cases (91.7%) ANA fluorescence karyotype of particle or particle/homogeneous, which was significantly higher than the 51.8% of the patients without lupus nephritis (P<0.05). Conclusion The homogeneous pattern of ANA was probably involved in the pathological process of class ⅡLN. And, the speckled pattern of ANA, or speckled pattern/ homogeneous pattern might participate in the pathogenesis of class Ⅴ LN. |
| keywords:Systemic lupus erythematosus Lupus nephritis Antinuclear antibody Immunifluorescence pattern |
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