| 硫辛酸对Ⅳ期糖尿病肾病患者蛋白尿及血、尿MCP-1的影响 |
| 投稿时间：2014-09-12 修订日期：2014-09-26 点此下载全文 |
| 引用本文：陈星华,张斯豪.硫辛酸对Ⅳ期糖尿病肾病患者蛋白尿及血、尿MCP-1的影响[J].医学研究杂志,2015,44(4):91-93 |
| DOI：
10.11969/j.issn.1673-548X.2015.04.024 |
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| 中文摘要:目的 观察硫辛酸对Ⅳ期2型糖尿病肾病患者的疗效以及对患者血、尿MCP-1水平的影响。 方法 选取笔者医院肾内科住院的Ⅳ期2型糖尿病肾病患者76例,随机均分为常规药物对照组和观察组(硫辛酸注射液 0.6g/d),每组患者38例,治疗时间3周,测定患者治疗前后24h尿蛋白定量、血肌酐、尿素氮、糖化血红蛋白、空腹血糖、血和尿单核细胞趋化蛋白-1(MCP-1)水平。 结果 两组患者治疗前后以上血生化指标无明显变化,经常规药物治疗,患者尿蛋白定量无明显变化,经硫辛酸治疗后,患者尿蛋白定量明显下降(1.89±0.72 vs 2.51±1.05g/24h,P<0.05),且较对照组治疗后(2.41±0.91g/24h)水平下降(P<0.05)。经常规药物治疗,患者血、尿MCP-1水平变化差异无统计学意义。经硫辛酸治疗后,患者血、尿MCP-1水平均下降(血液:39.50±13.68 vs 90.86±29.83pg/ml;尿液:63.41±19.57 vs 119.29±35.42pg/ml,P均<0.05),且较对照组治疗后血、尿MCP-1水平(91.45±33.41pg/ml;114.78±36.35pg/ml)下降(P均<0.05)。相关分析显示,患者血、尿MCP-1水平与其尿蛋白定量呈正相关(r=0.572,P<0.05;r=0.697, P<0.05)。 结论 Ⅳ期2型糖尿病肾病患者血、尿MCP-1的水平升高,硫辛酸可以降低患者的蛋白尿,其机制可能与降低患者血、尿MCP-1水平有关。 |
| 中文关键词:硫辛酸 糖尿病肾病 蛋白尿 单核细胞趋化蛋白-1(MCP-1) |
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| Effects of Lipoic Acid on Proteinuria,Serum and Urine MCP-1 Secretion in Patients with Stage IV Type 2 Diabetic Nephropathy |
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| Abstract:Objective To investigate the effect of on serum and urine MCP-1 secretion in patients with Stage IV Type 2 diabetic nephropathy treated by lipoic acid. Methods We enrolled 76 diabetic nephropathy patients,who were randomly divided into two groups. Patients in group T (24 males and 14 females) were treated by lipoic acid 0.6 gram per day. Those in group C (22 males and 16 females) were treated by routine drugs. The serum creatinine (Scr), urea nitrogen (BUN), fasting blood sugar(FBS) and 24h urinary protein,serum and urine MCP-1 secretion were measured at the experiment onset and 3 weeks later. Results There was no significant difference in the serum creatinine, urea nitrogen, fasting blood sugar, HbA1c between the two groups neither at the experiment onset nor after 3 weeks. Compared to experiment onset, 24h urine protein (Tp/24h), serum and urine MCP-1 secretion were all significantly decreased (P<0.05) in group T after 3 weeks. Compared to group C (2.41±0.91g/24h, 91.45±33.41pg/ml, 114.78±36.35pg/ml),all the levers in group T (1.89±0.72g/24h, 39.50±13.68pg/ml, 63.41±19.57pg/ml) was significantly decreased (P<0.05) after 3 weeks. There was a positive correlation between the serum, urine MCP-1 levels and Tp/24h (r=0.572, P<0.05;r=0.697,P<0.05). Conclusion Lipoic acid can reduce urine protein excretion in diabetic nephropathy patients, maybe by decreasing serum and urine MCP-1 secretion. |
| keywords:Lipoic acid Diabetic nephropathy Proteinuria Monocyte chemoattractant protein-1 (MCP-1) |
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