| 初诊狼疮肾炎患者左心室肥厚的相关因素 |
| 投稿时间：2014-09-03 修订日期：2014-10-08 点此下载全文 |
| 引用本文：沈晓琦,陈伟钱,陈江华.初诊狼疮肾炎患者左心室肥厚的相关因素[J].医学研究杂志,2015,44(4):97-99 |
| DOI：
10.11969/j.issn.1673-548X.2015.04.026 |
| 摘要点击次数: 1422 |
| 全文下载次数: 1279 |
|
|
| 中文摘要:目的 探讨初诊系统性红斑狼疮狼疮肾炎(lupus nephritis, LN)患者左心室肥厚的发生率及可能的相关因素。 方法 选取初诊狼疮肾炎患者,共210例,采用横断面调查分析方法。采集患者一般情况、血生化检验结果及同时期心脏彩色多普勒超声检测结果,按左心室心肌质量指数(left ventricular mass index, LVMI)分为两组:左心室肥厚组(n=89)和左心室正常组(n=121),比较两组生化指标的差异。使用Spearman秩相关和多元线性回归分析评价左心室肥厚的相关因素。 结果 左心室肥厚组LN患者血尿酸、超敏C反应蛋白(hyper-sensitive C-reactive protein, hs-CRP)高于对照组,血红蛋白、估算的肾小球滤过率(estimated glomerular filtration rate, eGFR)低于对照组,差异有统计学意义(P<0.05)。Spearman秩相关分析提示LVMI与尿酸、hs-CRP呈正相关(r=0.283、0.327,P<0.05),与血红蛋白,eGFR呈负相关(r=-0.232、-0.186,P<0.05)。多元线性回归分析提示hs-CRP、血红蛋白与狼疮肾炎患者左心室肥厚相关(r=0.235、-0.206,P<0.05)。 结论 炎症状态、贫血是初诊狼疮肾炎患者左心室肥厚的独立危险因素。改善患者炎症状态、纠正贫血可能利于减少左心室肥厚的发生。 |
| 中文关键词:系统性红斑狼疮 狼疮肾炎 左心室肥厚 心血管疾病 |
| |
| Influence Factors of Left Ventricular Hypertrophy in Incipient Lupus Nephritis Patients |
|
|
| Abstract:Objective To investigate the influence factors of left ventricular hypertrophy (LVH) in incipient systemic lupus erythematosus (SLE) patients with lupus nephritis (LN). Methods A total of 210 LN patients in the authors' centre were enrolled in this cross-section study. General information, laboratory measurements, examinations of left ventricular hypertrophy by ultrasonography were collected. Patients were divided into two groups according to left ventricular mass index (LVMI): left ventricle thickening (LVT) group (n=89) and left ventricle normal group (n=121). General information and laboratory results of two groups were statistically analyzed. Influence factors of the patients were analyzed with Spearman rank correlation and multiple linear regression. Results Serum uric acid and hyper-sensitive C-reactive protein (hs-CRP) were higher in left ventricular thickening(LVT)group, as compared with those in left ventricle normal group. Hemoglobin and estimated glomerular filtration rate (eGFR) in LVT group were significantly lower than those in left ventricle normal group (P<0.05). Spearman rank correction indicated that LVH was positively correlated with serum uric acid and hs-CRP (r=0.283、0.327, all P<0.05). LVH was negatively correlated with hemoglobin and eGFR (r=-0.232,-0.186, all P<0.05). Multiple linear regression showed hs-CRP and hemoglobin correlated with LVH (β=0.235、-0.206, all P<0.05). Conclusion Inflammatory state and anemia were risk factors of LVH in LN patients. |
| keywords:Systemic lupus erythematosus Lupus nephritis Left ventricular hypertrophy Cardiovascular disease |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
