探讨慢性阻塞性肺疾病患者血清中1α, 25-二羟维生素D水平及其影响因素
投稿时间:2014-08-20  修订日期:2014-09-28  点此下载全文
引用本文:蒋加雁,李雨,卢岚.探讨慢性阻塞性肺疾病患者血清中1α, 25-二羟维生素D水平及其影响因素[J].医学研究杂志,2015,44(4):107-110,113
DOI: 10.11969/j.issn.1673-548X.2015.04.029
摘要点击次数: 894
全文下载次数: 698
作者单位E-mail
蒋加雁 325405 温州医科大学附属第二医院平阳院区呼吸内科 jjy203203@sina.com 
李雨 325405 温州医科大学附属第二医院平阳院区呼吸内科  
卢岚 325405 温州医科大学附属第二医院平阳院区呼吸内科  
中文摘要:目的 1α, 25-二羟维生素D [1α,25(OH)2D3]是维生素D信号生物学功能的主要执行者,其血清水平不仅受其前体25-羟维生素D[25(OH)D]水平的调控,还受体内炎性状态的影响。本研究旨在分析慢性阻塞性肺疾病(COPD)患者中血清1α,25(OH)2D3水平及其影响因素。 方法 收集124例COPD患者和188名健康对照者,采用酶联免疫吸附法检测血清1α,25(OH)2D3及25(OH)D水平,同期收集COPD患者血清C反应蛋白(CRP)、白细胞计数(WBC)、血红蛋白量(Hb)及白蛋白(Alb)等实验室资料。 结果 经两独立样本t检验,与对照组相比,COPD组中血清1α,25(OH)2D3和25(OH)D平均水平明显降低,分别为:28.33±5.87 vs 30.58±6.48pg/ml, t=3.108, P=0.002; 25.73±5.44 vs 27.14±5.89ng/ml, t=2.128, P=0.034。根据患者病程分层分析,与稳定期COPD相比,急性加重期患者中血清1α,25(OH)2D3和25(OH)D平均水平亦显著降低,分别为:27.04±4.67 vs 29.17±5.01pg/ml, t=2.377, P=0.019; 24.31±4.22 vs 26.66±4.56ng/ml, t=2.888, P=0.005。采用Spearman相关分析法检验COPD组中血清1α,25(OH)2D3水平的相关影响因素,纳入的变量包括血清25(OH)D水平及CRP、WBC、Hb、Alb等血清学指标。结果显示COPD组中血清1α,25(OH)2D3水平与25(OH)D和CRP呈正相关(r=0.291, P=0.002; r=0.352, P=0.004),与Alb呈负相关(r=-0.346, P=0.001),而与WBC和Hb无关(P>0.05)。 结论 COPD患者中血清1α,25(OH)2D3水平与血清25(OH)D、CRP和Alb水平密切相关,并可能影响患者的病程。
中文关键词:慢性阻塞性肺疾病  1α25-二羟维生素D  25-羟维生素D
 
Investigation on the Serum 1α,25-dihydroxyvitamin D Levels and Its Effect Factors in Patients with Chronic Obstructive Pulmonary Disease
Abstract:Objective 1α,25-dihydroxyvitamin D [1α,25(OH)2D3] is the main performer of biological functions of vitamin D signal. It has been suggested that the serum 1α,25(OH)2D3 levels were affected by its precursor levels, 25-hydroxylvitamin D [25(OH)D], and the status of microenvironmental inflammatory. Our study aimed to analyze the serum 1α,25(OH)2D3 levels and their influencing factors in patients with chronic obstructive pulmonary disease (COPD). Methods After recruiting 124 COPD patients and 188 healthy controls, we examined the serum levels of 1α,25(OH)2D3 and 25(OH)D using enzyme-linked immunosorbent assay (ELISA). The laboratory data, such as C-reaction protein (CRP), white blood cells (WBC), hemoglobin (Hb) and albumin (Alb), were collected during the corresponding time. Results Average serum levels of 1α,25(OH)2D3 and 25(OH)Din COPD patients were lower than those in the controls (28.33±5.87 vs 30.58±6.48pg/ml, t=3.108, P=0.002; 25.73±5.44 vs 27.14±5.89ng/ml, t=2.128, P=0.034, respectively). In the stratified analysis for the course of disease in COPD patients, average serum levels of 1α,25(OH)2D3 and 25(OH)Din patients with acute exacerbation were shown to be significantly lower than in those with stable phase (27.04±4.67 vs 29.17±5.01pg/ml, t=2.377, P=0.019; 24.31±4.22 vs 26.66±4.56ng/ml, t=2.888, P=0.005, respectively). Subsequently, the Spearman rank correlation analysis was performed to evaluate the correlative factors influencing the serum levels of 1α,25(OH)2D3 in patients with COPD. The variables included serum levels of 25(OH)D and inflammatory related indicators,such as CRP, WBC, Hb and Alb. In result, serum levels of 1α,25(OH)2D3 in COPD patients were shown to be positively related with serum levels of 25(OH)D and CRP (r=0.291, P=0.002; r=0.352, P=0.004, respectively), and negatively correlated with Alb (r=-0.346, P=0.000), whereas not linked to WBC and Hb (P>0.05). Conclusion Serum 1α,25(OH)2D3 levels in patients with COPD were closely related with the levels of 25(OH)D, CRP and Alb, and may influence the course of disease.
keywords:Chronic obstructive pulmonary disease  1α,25-dihydroxyvitamin D  25-hydroxylvitamin D
查看全文  查看/发表评论  下载PDF阅读器

京公网安备 11010502037822号