| 慢性HBV感染不同状态下HBsAg定量的临床意义 |
| 投稿时间：2014-08-15 修订日期：2014-09-24 点此下载全文 |
| 引用本文：曹鸿挺,洪俊强,罗海波,刘运周,胡卫红,徐博宁,杨程.慢性HBV感染不同状态下HBsAg定量的临床意义[J].医学研究杂志,2015,44(4):142-145,155 |
| DOI：
10.11969/j.issn.1673-548X.2015.04.040 |
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| 中文摘要:目的 探讨HBsAg定量在慢性HBV感染自然史的不同阶段及HBV相关肝硬化中的临床意义。 方法 纳入慢性HBV感染患者185例,其中无肝硬化患者根据自然史分为免疫耐受组(n=34)、HBeAg阳性慢性乙型肝炎(chronic hepatitis B,CHB)组(n=25)、非活动携带组(n=24)及HBeAg阴性CHB组(n=34),肝硬化患者分为HBeAg阳性组(n=33)及HBeAg阴性组(n=35)。检测患者血清HBsAg、HBV DNA、ALT等指标。 结果 无肝硬化的慢性HBV感染患者HBsAg水平由高到低为:免疫耐受组[(4.60±0.32)log10IU/ml)]、HBeAg阳性CHB组[(4.36±0.45)log10IU/ml]、非活动携带组[(3.51±0.30)log10IU/ml]、HBeAg阴性CHB组[(3.62±0.35)log10IU/ml]。无肝硬化患者,年龄与HBsAg水平呈负相关(P=0.000);ALT与HBsAg水平无相关性(P=0.152)。免疫耐受及HBeAg阳性CHB组HBsAg水平与HBV DNA呈正相关(P=0.000,P=0.009)。HBeAg阳性肝硬化患者HBsAg水平[(4.27±1.33) log10IU/ml]与HBeAg阴性患者[(3.81±1.07) log10IU/ml]相似,HBsAg与年龄及ALT无相关性(P>0.05)。 结论 HBsAg水平在HBeAg阳性患者中可反映HBV DNA复制情况。无论有无肝硬化存在,HBsAg水平都不能反映肝组织炎性情况。 |
| 中文关键词:乙型肝炎病毒 乙型肝炎表面抗原 自然史 肝硬化 |
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| Clinical Implications of HBsAg Quantitation Under Different Conditions of Chronic HBV Infection |
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| Abstract:Objective To investigate the clinical implications of HBsAg quantitation in the natural history of chronic HBV infection and HBV-related cirrhosis. Methods A total of 185 patients with chronic HBV infection were included. Patients without cirrhosis were divided into the immune tolerance group (n=34), HBeAg-positive chronic hepatitis B (chronic hepatitis B, CHB) group (n=25), inactive carrier group (n = 24) and HBeAg-negative CHB group (n=34); patients with cirrhosis were divided to HBeAg-positive (n=33) and HBeAg-negative groups (n=35). We detected serum HBsAg, HBV DNA, ALT and other indicators. Results For patients without cirrhosis, HBsAg levels were (4.60±0.32) log10IU/ml in immune tolerance group, (4.36±0.45) log10IU/ml in HBeAg-positive CHB group, (3.51±0.30) log10IU/ml in the inactive carries group, and (3.62±0.35) log10IU/ml in HBeAg-negative CHB group. For patients without cirrhosis, their age was correlated with HBsAg level (P=0.000), but no correlation existed between ALT and HBsAg (P=0.152). HBsAg levels of immune tolerance and HBeAg-positive CHB groups were correlated with HBV DNA levels (P=0.000,P=0.009). HBsAg levels of HBeAg-positive (4.27±1.33) log10IU/ml and HBeAg-negative (3.81±1.07) log10IU/ml groups were similar in cirrhotic patients, and HBsAg was not correlated with age or ALT (P>0.05). Conclusion HBsAg level in HBeAg-positive patients may reflect HBV DNA replication. In patients with or without cirrhosis, HBsAg can not reflect the inflammation of the liver. |
| keywords:Hepatitis B virus Hepatitis B surface antigen Natural history Cirrhosis |
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