| OSAHS患者性激素水平与性功能障碍的研究 |
| 投稿时间：2014-11-12 修订日期：2014-11-24 点此下载全文 |
| 引用本文：丁旭萍,金镇华,唐婷玉,钦光跃.OSAHS患者性激素水平与性功能障碍的研究[J].医学研究杂志,2015,44(5):81-85 |
| DOI：
10.11969/j.issn.1673-548X.2015.05.021 |
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| 基金项目:浙江省医药卫生科技计划项目(2012KYB004) |
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| 中文摘要:目的 探讨OSAHS患者血清性激素水平与性功能障碍的关系。方法 选取78例男性OSAHS患者及30例男性健康对照人群, 分别行多导睡眠图仪(PSG)监测,包括呼吸暂停低通气指数(AHI)、氧减指数(ODI4)、最低血氧饱和度(LSaO2)、微觉醒指数(MAI),血清性激素水平测定,包括卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、雌二醇(E2)、孕酮(P)和睾酮(Ts), 同时采用国际勃起功能指数-5 (IIEF-5)量表评估所有受试者性功能。结果 OSAHS患者BMI、颈围、腹围升高(P<0.01),PSG各参数指标亦增高(P<0.01);而血清性激素FSH、LH、E2、P等水平均降低(P<0.01)。轻中度和重度OSAHS患者的性功能障碍发生率分别为32.26%和55.32%,均较健康对照组人群明显增高(F=5.58,P<0.01)。性功能障碍严重程度与年龄、AHI严重程度呈正相关(r=0.697,r=0.367),与FSH水平呈负相关(r=-0.412)。结论 OSAHS患者存在明显性功能障碍,其发生可能与性激素水平相关。 |
| 中文关键词:阻塞性睡眠呼吸暂停低通气综合征 性激素 性功能障碍 |
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| Research of Sex Hormone Levels and Erectile Dysfunction in Patients with Obstructive Sleep Apnea-hypopnea Syndrome |
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| Abstract:Objective To discuss the relationship between the serum level of sex hormones and erectile dysfunction in patients with OSAHS. Mehthods Subjectires of the study were divided into two groups-OSAHS(78 cases) and healthy controls(30 cases) according to polysomnography(PSG). Polysomnography monitoring (including apnea hypopnea index, oxygen desaturation index, lowest oxygen saturation and microarousal index), serum sex hormone levels (including follicle-stimulating hormone, luteinizing hormone, prolactin, estradiol, progesterone, and testosterone) and international index of erectile function-5 of all the objects were detected. Results The levels of BMI, neck circumference, abdominal circumference and PSG parameters in patients with OSAHS were significantly higher than those in healthy controls(P<0.01). The levels of FSH, LH, E2 and P in patients with OSAHS were significantly lower than those in healthy controls (P<0.01). The frequency of erectile dysfunction were significantly higher in patients with OSAHS than in the healthy controls (F=5.58, P<0.01). The severity of erectile dysfunction was associated with age, AHI and the levels of FSH (r=0.697, r=0.367, r=-0.412). Conclusion Erectile dysfunction is more frequent in OSAHS patients, and it seems to be related to the levels of sex hormone. |
| keywords:Obstructive sleep apnea-hypopnea syndrome Sex hormone Erectile dysfunction |
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