| ALT持续正常的HBeAg阴性的HBV感染者肝组织损伤情况及其危险因素分析 |
| 投稿时间：2015-01-04 修订日期：2015-01-27 点此下载全文 |
| 引用本文：徐智华,李文渊,叶卫江.ALT持续正常的HBeAg阴性的HBV感染者肝组织损伤情况及其危险因素分析[J].医学研究杂志,2015,44(5):98-101 |
| DOI：
10.11969/j.issn.1673-548X.2015.05.026 |
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| 基金项目:浙江中医药大学校级科研基金资助项目(2014ZY03) |
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| 中文摘要:目的 探讨ALT持续正常的HBeAg阴性慢性乙型肝炎病毒(hepatitis B virus,HBV)感染者肝组织损伤情况及其危险因素。方法 对94例ALT持续正常的HBeAg阴性慢性HBV感染者进行肝活检,比较肝组织病理不同的患者之间的性别、年龄、家族史、HBV-DNA水平、HBsAg的差别,并采用Logistic模型进行独立危险因素的分析。结果 94例患者中炎性坏死分级≥G2的占74.5%,纤维化分级≥S2的占27.7%。炎性坏死分级≥G2组比结论 ALT正常的HBeAg阴性的HBV感染者,无论ALT及HBV-DNA水平的高低,实施肝组织穿刺活检是必需的。尤其是对病毒水平高且有乙型肝炎家族史者应积极开展肝穿刺。 |
| 中文关键词:乙型肝炎病毒携带者 肝组织病理 危险因素 |
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| Histological Injury and Its Risk Factors of HBeAg-negative Chronic Hepatitis B Virus-infected Patients with Persistently Normal Alanine Aminotransferase Levels |
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| Abstract:Objective To investigate the histological injury as well as the risk factors for the course of HBeAg-negative chronic hepatitis B virus(HBV)-infected patients with persistently normal alanine aminotransferase (ALT) levels (PNAL). Methods Ninty four patients of HBeAg-negative chronic HBV-infected with PNAL were performed liver puncturing. The ALT, HBV markers, and liver histological changes were detected. The gender, age, family history, HBV-DNA and HBsAg levels were compared between different patients with liver inflammation and fibrosis. And the Logistic model was used during the analysis of independent risk factor. Results Among 94 cases, patients with inflammatory necrosis classification ≥G2 accounted for 74.5%, fibrosis grading ≥S2 accounted for 27.7%. Patients in the group of inflammatory necrosis classification ≥G2 was older than the group of Conclusion The patients of HBeAg-negative chronic HBV-infected with PNAL, regardless of the ALT and HBV-DNA, must have a liver biopsy. The patients with high level of HBV-DNA and with a family history of hepatitis B should be performed liver puncturing accordingly. |
| keywords:Hepatitis B carriers Liver pathology Risk factors |
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