| 雷利度胺联合方案治疗恶性浆细胞肿瘤的临床疗效观察 |
| 投稿时间：2014-10-30 修订日期：2014-11-15 点此下载全文 |
| 引用本文：卢博,金梦迪,王淡瑜,王欣,崔海燕,刘泽林.雷利度胺联合方案治疗恶性浆细胞肿瘤的临床疗效观察[J].医学研究杂志,2015,44(5):127-130 |
| DOI：
10.11969/j.issn.1673-548X.2015.05.035 |
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| 中文摘要:目的 评估含有雷利度胺的联合化疗方案治疗恶性浆细胞肿瘤的临床疗效。方法 回顾性分析15例既往接受过治疗的恶性浆细胞肿瘤,13例为多发性骨髓瘤患者,1例为原发性浆细胞白血病,1例为髓外浆细胞瘤。给予含雷利度胺的联合方案化疗。雷利度胺给药的方案为第1~第21天25mg。联合方案为CRD、PAD+R+CTX+IDA。结果 15例患者共完成68个治疗周期,中位治疗周期为4个周期。15例患者中,2例获得CR、1例获得nCR、6例获得PR、2例MR、2例NC、2例PD。总有效率达73.3%。不良反应主要是骨髓抑制和感染。结论 雷利度胺联合方案治疗恶性浆细胞肿瘤的疗效确切,不良反应可耐受。 |
| 中文关键词:雷利度胺 恶性浆细胞肿瘤 疗效 不良反应 |
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| Clinical Efficacy of Combination Therapy with Lenalidomide Regimen in Treatment of Malignant Plasma Cell tumor |
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| Abstract:Objective To investigate the clinical efficacy and adverse events of combination therapy with lenalidomide in malignant plasma cell tumor. Methods Fifteen cases of malignant plasma cell tumors who had received therapy before were analysed retrospectively, including 13 cases with multiple myeloma, 1 case with plasma cell leukemia, 1 case with extramedullary plasmacytoma. 15 cases of malignant plasma cell tumors were treated with CRD,PAD+R+CTX+IDA regiments containing lenalidomide (25mg/d d1-21) in a 28-day cycle. Results Fifteen patients completed 68 treatment cycles. The median treatment cycle was 4. Two cases obtained complete remission(CR), 1case near complete remission(nCR), 6 cases partial remission(PR), 2 cases minimal remission(MR), 2 was of no change(NC) and 2 had progressive disease(PD).The total effective rate was 73.3%. The main adverse events were bone marrow suppression and infection. Conclusion The regiments containing lenalidomide were effective and safe methods in treating malignant plasma cell tumor. |
| keywords:Lenalidomide Malignant plasma cell tumor Curative effect Adverse events |
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