| CD14启动子-260C/T基因多态性与胃癌易感性的Meta分析 |
| 投稿时间：2015-01-06 修订日期：2015-01-12 点此下载全文 |
| 引用本文：王明珠,谭诗云,李明,郭芳,舒咏翔.CD14启动子-260C/T基因多态性与胃癌易感性的Meta分析[J].医学研究杂志,2015,44(6):42-46 |
| DOI：
10.11969/j.issn.1673-548X.2015.06.013 |
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| 基金项目:湖北省自然科学基金资助项目(ZRZ0050) |
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| 中文摘要:目的 CD14启动子-260C/T基因多态性与胃癌易感性的关系已被广为研究,但是其结果并不尽相同。为了更精确评估二者的关系,笔者进行了Meta分析。方法 计算机全面检索PubMed、Medline、EMbase、CBM、CNKI、万方和维普等数据库,并辅以手检。检索时间从建库截至2015年1月1日,收集 CD14启动子-260C/T基因多态性与胃癌易感性病例对照研究。采用RevMan 5.2软件计算合并效用量OR 及其95%CI,采用Stata 12.0合成漏斗图。结果 共纳入10个研究,其中病例组2365例,对照组3497例。Meta分析发现,在4个遗传模型中,CD14启动子-260C/T基因多态性与胃癌风险的相关性差异均无统计学意义(显性模型:OR=1.07, 95%CI:0.83~1.39; 隐形模型:OR=1.08,95%CI:0.89~1.30;TT vs CC模型OR=1.11,95%CI:0.79~1.56;CT vs CC模型:OR=1.06,95%CI:0.83~1.35)。进一步以种族及对照来源行分层分析,亦未发现CD14启动子-260C/T基因多态性与胃癌风险存在相关性(显性模型: HB对照源:OR=1.02,95%CI:0.63~1.65,PB对照源:OR=1.12, 95%CI:0.85~1.49;亚洲人:OR=1.12, 95%CI:0.73~1.71;白种人:OR=1.02,95%CI:0.80~1.30)。结论 CD14启动子-260C/T基因多态性与胃癌易感性无关,基因型TT和CT+TT并不增加罹患胃癌的风险。 |
| 中文关键词:CD14-260C/T 基因多态性 胃癌 Meta分析 |
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| Association between CD14 Promoter-260 C/T Gene Polymorphism and Susceptibility of Gastric Cancer:a Meta-Analysis |
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| Abstract:Objective The CD14 promoter -260 C/T gene polymorphism have been shown to confer genetic susceptibility to gastric cancer, but the results are inconsistent. In order to accomplish a more precise estimation of the relationship, a meta analysis was performed. Methods All eligible case-control studies published up to Jan. 2015 were identified by searching PubMed, Medline, EMbase, BM, CNKI, VIP, etc. Meta-analysis was performed by RevMan 5.2 and stata 12.0 software. Results A total of 10 studies including 2365 cases of patients and 3497cases of controls. There was no significant association between CD14 promoter-260 C/T gene polymorphism and gastric cancer susceptibility was found in overall meta-analysis (dominant models: OR=1.07,95%CI:0.83-1.39; recessive models:OR=1.08,95%CI:0.89-1.30; TT vs CC models: OR=1.11,95%CI:0.79-1.56;CT vs CC models:OR=1.06,95%CI:0.83-1.35). In subgroup analyses of source of controls and ethnicity, we didn't found a significant association between CD14 promoter-260 C/T gene polymorphism and gastric cancer susceptibility (dominant models: HB source: OR=1.02,95%CI:0.63-1.65,PB source:OR=1.12, 95%CI:0.85-1.49; Caucasian:OR=1.02,95%CI:0.80-1.30, Asian:OR=1.12, 95%CI:0.73-1.71). Conclusion The CD14 promoter -260 C/T gene polymorphism was not related to susceptibility of gastric cancer, and genotype TT and CT+TT didn't increase the risks of suffering from gastric cancer. |
| keywords:CD14-260C/T Gene polymorphism Gastric cancer Meta analysis |
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