| 胸科手术中脑血氧含量下降与术后认知功能障碍的相关性分析 |
| 投稿时间：2014-12-17 修订日期：2015-01-14 点此下载全文 |
| 引用本文：张跃军,李航.胸科手术中脑血氧含量下降与术后认知功能障碍的相关性分析[J].医学研究杂志,2015,44(6):60-62 |
| DOI：
10.11969/j.issn.1673-548X.2015.06.017 |
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| 基金项目:浙江省医药卫生科技计划项目(2011KYB152) |
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| 中文摘要:目的 分析胸科手术单肺通气时的绝对脑血氧饱和度(absolute oximetry, SctO2)下降程度与术后认知功能障碍是否存在相关性。方法 研究对象为76例经历单侧肺通气胸科手术的患者,且通气时间>45min。记录指标包括SctO2值和常规临床指标。简易精神状态测验(Mini-Mental State Exam, MMSE)用于评测术后3h和24h认知状态。SctO2下降程度和术后认知功能障碍的相关性使用Spearman相关分析。结果 单肺通气时,其中40例SctO2<65%,15例SctO2<60%,5例SctO2<55%。术后3h,29%的患者存在MMSE评分下降超过2分,术后24h,10%的患者存在MMSE评分下降超过2分。术后认知功能障碍与SctO2<65%的相关系数r2=0.272,SctO2<60%的相关系数r2=0.285,以及SctO2<55%的相关系数r2=0.297,都呈现明显的相关性。结论 胸科手术单肺通气时SctO2下降程度与术后认知功能障碍发生呈正相关。 |
| 中文关键词:术后认知功能障碍 单肺通气 胸科手术 |
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| Correlation Analysis of Reduced Cerebral Absolute Oximetry During Thoracic Surgery and Postoperative Cognitive Dysfunction |
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| Abstract:Objective To determine the relationship between postoperative cognitive dysfunction and decreased absolute oximetry (SctO2) during thoracic surgery. Methods A total of 76 patients received single-lung ventilation thoracic surgery with surgery time>45min were enrolled. Monitoring parameters included SctO2 and general clinical statues. The Mini-Mental State Exam (MMSE) test was used to assess the cognitive function before operation and at 3 and 24 h after operation. The relationship between SctO2 and cognitive function was analyzed by Spearman correlation test. Data were presented as interquartile range, and P<0.05 represented statistical significance. Results SctO2 during SLV decreased exceed 65%, 60% and 55% in 40, 15 and 5 patients. 3h after surgery, there were 29% patients who had a decrease of MMSE exceed 2 points. 24h after surgery, there were 10% patients who had a decrease of MMSE exceed 2 points. Correlation coefficient of postoperative cognitive dysfunction and SctO2 < 65%, < 60%, < 55% were 0.272, 0.285, 0.297, all obviously. Conclusion Intraoperative decline of SctO2 during SLV thoracic surgery is positively related to postoperative cognitive dysfunction. |
| keywords:Postoperative cognitive dysfunction Single-lung ventilation Thoracic surgery |
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