| 选择性口咽/消化道去污染对重症监护病房中抗生素耐药效果影响的Meta分析 |
| 投稿时间：2014-11-07 修订日期：2014-12-02 点此下载全文 |
| 引用本文：范勇,周青山,吕霞,何仁政.选择性口咽/消化道去污染对重症监护病房中抗生素耐药效果影响的Meta分析[J].医学研究杂志,2015,44(6):79-85 |
| DOI：
10.11969/j.issn.1673-548X.2015.06.023 |
| 摘要点击次数: 970 |
| 全文下载次数: 713 |
|
|
| 中文摘要:目的 评价选择性口咽/消化道去污染在重症监护病房中的应用对细菌抗生素耐药的影响。方法 计算机系统检索Medline、Embase、Cochrane在线图书馆、中国学术期刊全文数据库、中国生物医学文献数据库等电子数据库,图书馆人工检索相关专业杂志。由两位检索人员根据纳入标准,通过阅读标题、摘要或全文,检索与重症监护病房中应用选择性消化道去污染相关的随机对照试验(RCT),评价并提取纳入研究中的耐药相关数据。采用RevMan 5.1软件中的随机效应模型进行相关数据合并和分析。结果 共纳入11篇与选择性去污染与重症病房细菌耐药有关的RCT文献。与未接受选择性去污染的患者相比,接受选择性去污染患者的革兰阳性细菌定植或耐药发生率并无显著增高,革兰阴性菌的氨基糖苷类耐药情况亦无显著增加,甚至具有降低耐药菌感染率的作用。结论 选择性口咽/消化道去污染不增加重症监护病房中细菌抗生素耐药的发生率。 |
| 中文关键词:选择性去污染 抗生素 耐药 重症监护 Meta分析 |
| |
| A Meta-analysis of Effect of Selective Decontamination of the Oropharynx and the Digestive Tract on Antimicrobial Resistance in Intensive Care Units |
|
|
| Abstract:Objective To study whether application of selective decontamination of the oropharynx and the digestive tract in intensive care units could affect the antimicrobial resistance. Methods We systematically searched the electronic databases including Medline, Embase, the Cochrane online library, China knowledge resource integrated database and Chinese biomedical literature database by computer, and professional journals in library by hand. According to the inclusion criteria, two reviewers independently identified the literatures via assessing titles, abstracts or full-texts, included randomized controlled clinical trials(RCTs) which were relevant to the topics of this study, evaluated the quality of eligible studies and extracted comparable data related to antimicrobial resistance. The review manager 5.1 software was used to perform the pooled analysis in the setting of random effects model. Results After comprehensive identification, a total of 47 articles relevant to selective decontamination in intensive care units and antimicrobial resistance were included. Compared with patients without receiving selective oropharynx and digestive decontamination, those who received selective decontamination did not exhibit significant differences in occurrence of antimicrobial resistances, in contract, selective decontamination was associated with reduction in incidence of antimicrobial resistances. Conclusion Selective oropharynx and digestive decontamination is not associated with increased risk of antimicrobial resistances in intensive care units. Large scale, multi-center, randomized controlled clinical trials are needed to assess this recommendation. |
| keywords:Selective decontamination Antimicrobial Drug resistance Intensive care Meta-analysis |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
