肠易激综合征与小肠细菌过度生长关系的Meta分析
投稿时间:2014-11-09  修订日期:2014-11-18  点此下载全文
引用本文:唐勤彩,罗和生,全晓静,陈炜.肠易激综合征与小肠细菌过度生长关系的Meta分析[J].医学研究杂志,2015,44(6):89-94
DOI: 10.11969/j.issn.1673-548X.2015.06.025
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作者单位E-mail
唐勤彩 430060 武汉大学人民医院消化内科  
罗和生 430060 武汉大学人民医院消化内科 xhnk@163.com 
全晓静 430060 武汉大学人民医院消化内科  
陈炜 430060 武汉大学人民医院消化内科  
中文摘要:目的 评价肠易激综合征与小肠细菌过度生长之间的关系。方法 检索MEDLINE/PubMed、OVID、Cochrane Central Register of Controlled Trials、中国生物医学文献数据库等,按标准纳入肠易激综合征与小肠细菌过度生长的所有病例对照研究。采用Cochrane协作网提供的RevMan5.1软件进行荟萃分析。结果 8项病例对照研究共1369例患者纳入分析。结果显示,肠易激综合征会增加发生小肠细菌过度增长的风险(阳性率31.24%),与对照组比较差异有统计学意义(OR=2.97,95% CI:1.68~5.24,P<0.01);不同亚型的肠易激综合征比较,便秘型肠易激综合征和腹泻型肠易激综合征组细菌过度增长的阳性率分别为31.25%和36.19%,对照组阳性率为10.65%,与对照组比较,两组不同类型的肠易激综合征与对照组的差异均有统计学意义;不同地区比较,亚洲地区组(阳性率35.00%)和欧美地区组(阳性率26.35%)与对照组比较差异均有统计学意义;不同诊断方法组比较,GBT组与对照组差异比较,差异有统计学意义(OR=5.19,95% CI:2.93~9.20,P<0.01),而LBT组与对照组差异无统计学意义(P=0.070)。结论 肠易激综合征患者中小肠细菌过度生长的发生率明显增高,但与地域差异及肠易激综合征的亚型关系不大。
中文关键词:肠易激综合征  小肠细菌过度生长  Meta分析
 
Irritable Bowel Syndrome and Risk of Small Intestinal Bacterial Overgrowth: a Meta-analysis of Observational Studies
Abstract:Objective To assess the associations between irritable bowel syndrome and risk of small intestinal bacterial overgrowth using meta-analysis. Methods We searched MEDLINE (PubMed), OVID, the Cochrane Library and China Biological Medicine in December 2013. Two evaluators independently reviewed and selected articles, based on pre-determined selection criteria. Results Eight observational studies, which involved 1369 participants, were included in the final analysis. The overall IBS was significantly associated with the risk of small intestinal bacterial overgrowth in a random-effects model in the meta-analysis of all 8 observational studies (OR=2.97,95% CI:1.68-5.24,P<0.01). Forthe different subtypes of irritable bowel syndrome, compared with the control group, there was association between both constipation-predominant IBS or diarrhea-predominant IBS and the risk of small intestinal bacterial overgrowth.Based on different regions, there was association between Asian region or European and American area and the risk of small intestinal bacterial overgrowth.Based on different diagnostic methods of small intestinal bacterial overgrowth, there was no association between GBT and the risk of bacterial overgrowth(P=0.070). Conclusion There was association between IBS and SIBO. There was no significant difference between different subtypes of IBS and people from different areas with SIBO.
keywords:Irritable bowel syndrome  Small intestinal bacterial overgrowth  Meta analysis
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