| 老年心力衰竭合并AECOPD患者血清PINP、β-CTX的水平变化及临床意义 |
| 投稿时间：2014-11-07 修订日期：2014-12-02 点此下载全文 |
| 引用本文：何正飞.老年心力衰竭合并AECOPD患者血清PINP、β-CTX的水平变化及临床意义[J].医学研究杂志,2015,44(6):134-137 |
| DOI：
10.11969/j.issn.1673-548X.2015.06.038 |
| 摘要点击次数: 1016 |
| 全文下载次数: 937 |
|
|
| 中文摘要:目的 探讨血清PINP、β-CTX在老年心力衰竭合并AECOPD中的水平变化及意义。方法 选择2011年1月~2013年12月期间62例老年心力衰竭合并COPD患者为研究对象。将62例患者按照COPD严重程度分为AECOPD 32例(A组),COPD缓解期30例(B组)。另选择同期在笔者医院体检的健康人群36例为对照组。统计受试者血清PINP、β-CTX含量,并对各指标与年龄、烟龄、肺功能、BMI的关系进行相关性分析。结果 观察组血清PINP、β-CTX含量明显低于对照组,差异有统计学意义(P<0.01)。A组血清PINP、β-CTX含量明显低于B组,差异有统计学意义(P<0.01)。老年心力衰竭合并AECOPD患者经治疗后血清PINP、β-CTX水平明显较治疗前提高,差异有统计学意义(P<0.01)。血清PINP水平与烟龄呈负相关(r=-0.298,P=0.035),与FEV1%预计值、FEV1/FVC(%)呈正相关(r=0.318,0.402;P=0.038,0.016);血清β-CTX水平与烟龄呈负相关(r=-0.297,P=0.026),与FEV1%预计值、FEV1/FVC(%)呈正相关(r=0.278,0.298;P=0.042,0.037)。结论 老年心力衰竭合并AECOPD血清PINP、β-CTX水平明显下降,患者骨质疏松症发病风险增大,血清PINP、β-CTX水平与老年心力衰竭合并AECOPD密切相关,监测上述指标可对老年心力衰竭合并COPD病情及骨质疏松症发病风险进行监测与判断。 |
| 中文关键词:慢性阻塞性肺疾病急性加重 心力衰竭 Ⅰ型胶原氨基端前肽 骨质疏松症 |
| |
| Change and Clinical Value of Serum PINP、β-CTX in Elderly Heart Failure with Acute Exacerbation of COPD |
|
|
| Abstract:Objective To study change and clinical value of PINP, β-CTX in serum in elderly heart failure with acute exacerbation of COPD. Methods From 2011 January to 2013 December, 62 cases of elderly heart failure with acute exacerbation of COPD were selected as the research object. Sixty two patients in accordance with the severity of COPD were divided into acute exacerbation of COPD in 32 cases (group A), 30 patients with COPD in remission stage (group B). In the same population in health medical examination in our hospital 36 cases were served as control group. Statistical subjects' PINP, β-CTXcontent in serum and the relations between the various indexes and age, smoking, pulmonary function, BMI correlation analysis were made. Results The observation group's serum PINP and β-CTX levels were significantly lower those that of the control group, and there were significant differences (P<0.01). A group's serum PINP and β-CTX was lower than that in B group, and there were significant differences (P<0.01). In elderly heart failure with acute exacerbation of COPD after treatment, serum PINP and β-CTX levels were significantly increased than before treatment, and there were significant differences (P<0.01). The serum level of PINP was negatively correlated with smoking (r=-0.298, P=0.035), and was positively correlated with FEV1% and FEV1/FVC (%)expected value (r=0.318, 0.402; P=0.038, 0.016). Serum β-CTX level was negatively correlated with smoking (r=-0.297, P=0.026), and was positively correlated with FEV1% and FEV1/FVC (%)expected value (r=0.278, 0.298; P=0.042, 0.037). Conclusion PINP and β-CTX levels of elderly heart failure with acute exacerbation of COPD were significantly decreased in patients. These patients have increasing the risk of osteoporosis. Serum PINP and β-CTX levels are closely related to elderly heart failure with acute exacerbation of COPD. They can be used for monitoring and the judgment of elderly heart failure with acute exacerbation of COPD disease and osteoporosis risk. |
| keywords:Acute exacerbation of chronic obstructive pulmonary disease Heart failure Collagen type I N-terminal propeptide Osteoporosis |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
