| 艾塞那肽对大鼠脑缺血再灌注损伤的保护作用研究 |
| 投稿时间：2014-10-08 修订日期：2014-11-28 点此下载全文 |
| 引用本文：周纪东.艾塞那肽对大鼠脑缺血再灌注损伤的保护作用研究[J].医学研究杂志,2015,44(6):142-144 |
| DOI：
10.11969/j.issn.1673-548X.2015.06.040 |
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| 中文摘要:目的 研究艾塞那肽对大鼠脑缺血再灌注损伤的保护作用。方法 60只Wistar大鼠经线栓法建立大鼠大脑缺血再灌注动脉模型,随机分为艾塞那肽组(n=30)和生理盐水组(n=30),再灌注后60min给药,比较两组再灌注后24h的Bederson评分、梗死灶体积、超氧化物歧化酶(SOD)、血管内皮生长因子(VEGF)等指标。结果 艾塞那肽组大鼠再灌注24h后Bederson评分、梗死灶体积、SOD水平较生理盐水组显著下降(P<0.05),VEGF水平较生理盐水组显著升高(P<0.05)。结论 艾塞那肽对大鼠脑缺血再灌注损伤有神经保护作用。 |
| 中文关键词:艾塞那肽 脑缺血再灌注 损伤 |
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| Neuroprotective Effects of Exenatide for Cerebral Ischemia Reperfusion Injury of Rats |
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| Abstract:Objective To investigate the neuroprotective effects of exenatide for cerebral ischemia reperfusion injury of rats. Methods Sixty Wistar rats were built a stroke and reperfusion model by suture method, At one hour after reperfusion, exenatide(n=30) or saline(n=30) was administered intraperitoneally. Bederson's test, infarct volumes, superoxide dismutase(SOD) and vascular endothelial growth factor (VEGF) were measured. Results The Bederson's scores, infarct volumes and SOD of exenatide-treated rats were significantly decreased than those of control rats(P<0.05). VEGF level of exenatide-treated rats was significantly increased, compared to that of control rats. Conclusion Exenatide has the neuroprotective effects for cerebral ischemia reperfusion injury of rats. |
| keywords:Exenatide Cerebral ischemia reperfusion Injury |
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