| 氩氦刀对肺气肿兔肺组织微创减容治疗的研究 |
| 投稿时间：2014-12-15 修订日期：2014-12-20 点此下载全文 |
| 引用本文：张孝天,臧琦.氩氦刀对肺气肿兔肺组织微创减容治疗的研究[J].医学研究杂志,2015,44(7):66-69 |
| DOI：
10.11969/j.issn.1673-548X.2015.07.019 |
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| 基金项目:山东省自然科学基金资助项目(ZR2010HL005) |
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| 中文摘要:目的 本研究旨在通过采用氩氦刀经皮肺穿刺对实验性兔肺气肿模型施行靶向冷消融,以确定氩氦刀经皮靶向肺减容术的有效性、可行性和安全性。方法 采用纯种健康新西兰成年大白兔20只建立肺气肿模型,分别在建立模型前后测肺功能及血气分析;模型建立后在CT引导下经皮穿刺行氩氦刀肺减容治疗,冷融全部采用2次冷融循环,冷冻为每次5min,复温过程采用氦气主动复温,复温时间为2min。分别于1、3、7、14、28天测定血气分析及肺功能结果,并且获取相应的标本观察其大体形态及其在光镜下的组织学变化。结果 氩氦刀冷冻消融治疗过程中,实验组术中少量出血3例(15%),皮下气肿2例(10%);肺功能及血气分析:与肺气肿模型相比,术后1天无明显改变(P>0.05),术后3、7天明显改变(P<0.05)、术后14、28天显著改变(P<0.01),肺功能和血气分析指标的最佳改善时间为7~14天。结论 氩氦刀肺减容术以达到有效破坏靶组织的目的,明显改善动物模型肺功能和血气分析指标,且创伤小、并发症少、效果好、安全性高。 |
| 中文关键词:兔 肺气肿 氩氦刀 肺减容术 血气分析 肺功能 |
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| Research of Cryoablation Minimally Invasive Lung Volume Reduction Surgery to Rabbit Emphysema Model |
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| Abstract:Objective To perform the percutaneous Argon-Helium cryoablation on experimental emphysema rabbits Model, in order to eveluate the Percutaneous cryoablation of lung volume reduction surgery(LRVS) effectiveness, feasibility and safety. Methods The emphysema model were established on 20 healthy adult new Zealand white rabbits. The lung function and blood gas analysis were measured before and after the emphysema model establishment.After the emphysema model was established, the rabbit were punctured by CT-guided for Argon-helium cryoablation, which was performed for 2 cycles; frozen process for 5 minutes each time;helium active thawing, for 2 minutes each time. The result of lung function and blood gas analysis were measured on 1,3,7,14,28 days respectively, meanwhile obtain the corresponding specimens to observe the general morphological and histological changes under light microscopy. Results During the Argon-Helium cryoablation of lung volume reduction surgery, 3 cases of mild intraoperative bleeding (15%) and 2 cases of subcutaneous emphysema (10%) happened. compared with emphysema model, lung function and blood gas analysis of the model did not change significantly 1 day post operation(P>0.05), on 3 days and 7 days post operation , lung function and blood gas analysis changed significantly (P<0.05); the lung function and blood gas analysis on 14 days, 28 days post operation have change significantly (P<0.01) against emphysema model, the best time to improve the result of lung function and blood gas analysis is between 7-14 days. Conclusion Percutaneous cryoablation of lung volume reduction surgery achieve the purpose of effectively destroy the target tissue, significantly improve the animal model of pulmonary function and blood gas analysis index, with small trauma, fewer complications, higher efficacy and safety. |
| keywords:Rabbit Emphysema Percutaneous cryoablation LRVS Blood gas analysis Lung function |
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