糖化血红蛋白水平与晚期胃癌FOLFOX方案化疗的近期有效率相关性研究
投稿时间:2014-10-01  修订日期:2014-10-23  点此下载全文
引用本文:汪青,郑磊贞,朱美玲,陈思宇,章莉.糖化血红蛋白水平与晚期胃癌FOLFOX方案化疗的近期有效率相关性研究[J].医学研究杂志,2015,44(7):104-107
DOI: 10.11969/j.issn.1673-548X.2015.07.029
摘要点击次数: 1148
全文下载次数: 1262
作者单位E-mail
汪青 200092 上海交通大学附属新华医院肿瘤科  
郑磊贞 200092 上海交通大学附属新华医院肿瘤科 zhengleizhen2006@126.com 
朱美玲 200092 上海交通大学附属新华医院肿瘤科  
陈思宇 200092 上海交通大学附属新华医院肿瘤科  
章莉 200092 上海交通大学附属新华医院肿瘤科  
中文摘要:目的 研究晚期胃癌患者不同的糖化血红蛋白水平与化疗的近期有效率的相关性。方法 对52例晚期胃癌患者进行回顾性分析,测定化疗前后的患者糖化血红蛋白水平的变化,观察该指标与近期有效率(RR)的相关性。结果 全组52例患者均完成至少3个周期化疗,并行疗效评价。该组患者FOLFOX方案化疗的近期有效率为32.7%,晚期胃癌患者化疗后糖化血红蛋白水平与患者不同的病灶数目的差异有统计学意义(P=0.039)。晚期胃癌患者糖化血红蛋白的低、中、高水平组RR分别为9、6、2例,3组患者化疗的近期有效率比较,差异有统计学意义(P<0.05);低、中、高糖化血红蛋白水平组疾病控制率分别为89.4%(17/19)、76.1%(16/21)、41.6%(5/12),组间比较,差异均有统计学意义(P<0.05)。结论 糖化血红蛋白水平较高的晚期胃癌患者近期有效率较差,糖化血红蛋白水平可能是潜在的化疗近期疗效预测指标之一。
中文关键词:胃癌  近期有效率  糖化血红蛋白
 
Association of the Glycosylated Hemoglobin Levels with the Short-term Effect of FOLFOX Chemotherapy in Advanced Gastric Cancer
Abstract:Objective To explore the correlation of the different glycosylated hemoglobin levels with the short-term effect of chemotherapy in advanced gastric cancer. Methods Past immunohistochemical data of 52 advanced gastric cancer patients after FOLFOX chemotherapy were analyzed retrospectively. According to the change of the glycosylated hemoglobin levels before and after chemotherapy, it could be observed the association of the glycosylated hemoglobin levels with the short-term effect of chemotherapy. Results The whole group of 52 patients had completed at least three cycles of chemotherapy, and then got completed efficacy evaluation. Recent response rate of the patients who got FOLFOX chemotherapy was 17 cases (32.7%). The glycosylated hemoglobin levels with the different number of metastasis (P=0.036) were significantly different. Advanced gastric cancer patients with low, medium and high level expression of glycosylated hemoglobin group RR was 9, 6, 2 cases. The three groups of efficient comparative difference was statistically significant (P<0.05). The low, medium and high glycosylated hemoglobin levels of disease control rates were 89.4% (17/19), 76.1% (16/21), 41.6% (5/12). The three groups of efficient comparative difference was statistically significant (P<0.05). Conclusion Advanced gastric cancer patients with high glycosylated hemoglobin levels were not sensitive to FOLFOX chemotherapy. The glycosylated hemoglobin levels may be a potential predictor of short-term effect in the chemotherapy.
keywords:Gastric cancer  Recent response rate  Glycosylated hemoglobin
查看全文  查看/发表评论  下载PDF阅读器

京公网安备 11010502037822号