| 发病前他汀类药物使用对缺血性脑卒中静脉溶栓疗效及安全性分析 |
| 投稿时间：2014-11-24 修订日期：2014-12-24 点此下载全文 |
| 引用本文：聂田,李保华,唐波,梅爱东,杨卉,黄盼盼,蒋敏海.发病前他汀类药物使用对缺血性脑卒中静脉溶栓疗效及安全性分析[J].医学研究杂志,2015,44(7):144-148 |
| DOI：
10.11969/j.issn.1673-548X.2015.07.041 |
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| 中文摘要:目的 研究发病前他汀类药物使用对急性缺血性脑卒中静脉溶栓患者的疗效与安全性的影响。方法 回顾性分析脑梗死溶栓患者187例,预后评价标准:短期有效(脑卒中时与1周 NIHSS评分差值≥4或8分)、长期有效(3个月mRS评分≤2或1分)、颅内出血、症状性颅内出血及死亡。筛选Pubmed和Embase中包含以上评价标准的文献,用Review Manager 5.2.6进行荟萃分析。结果 单因素分析中,脑卒中前服用他汀类药物在短期有效,差异有统计学意义(OR=2.01,95% CI:1.06~3.90,P=0.030)。多因素分析中,脑卒中前服用他汀类药物与各项预后评价指标无关。荟萃分析中,脑卒中前服用他汀类药物与症状性颅内出血(OR=1.49,95% CI:1.16~1.90,P=0.001)相关,与长期预后良好、死亡无关。结论 缺血性脑卒中溶栓患者发病前他汀类药物使用与预后关系不大,脑卒中前他汀类药物服用与静脉溶栓的联合治疗可能是安全的。 |
| 中文关键词:急性缺血性脑卒中 发病前他汀类药物使用 静脉溶栓 预后 荟萃分析 |
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| Efficacy and Safety of Prior Stain Use and Intravenous Thrombolysis in Acute Ischemic Stroke |
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| Abstract:Objective To examine whether prior statin use (PSU) affects efficacy and safety in stroke patients receiving intravenous thrombolysis (IV).Methods We conducted a retrospective analysis of 187 patients treated with IV. Outcome measures were short-term outcome (reduction ≥4 or 8 points on NIHSS within 7 days), long-term outcome (mRS ≤2 or 1 points); intracerebral hemorrhage (ICH), symptomatic ICH (sICH) and death. Pubmed and Embase were searched for clinical studies that involved the above-mentioned outcome measures. Data were calculated by Review Manager 5.2.6.Results Univariate analysis showed that PSU was associated with short-term effective outcome (OR=2.01, 95% CI: 1.06-3.90,P=0.030). Multivariate analysis indicated that there was no relation between PSU and outcome. Meta-analysis showed that PSU was associated with sICH (OR=1.49; 95% CI: 1.16-1.90, P=0.001). However, neither long-term effective outcome nor mortality was significant with PSU.Conclusion Our data suggest that PSU might neither positively nor negatively affect the outcome of stroke patients treated by IV. It might be safe to prior statin users receiving IV when stroke occurs. |
| keywords:Acute ischemic stroke Prior statin use Intravenous thrombolysis Outcome Meta-analysis |
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