| 多囊卵巢综合征患者肥胖及胰岛素抵抗因素对脂代谢的影响 |
| 投稿时间：2014-12-07 修订日期：2014-12-29 点此下载全文 |
| 引用本文：吴静,侯丽辉,王颖,李春艳,顾方韵.多囊卵巢综合征患者肥胖及胰岛素抵抗因素对脂代谢的影响[J].医学研究杂志,2015,44(8):35-37 |
| DOI：
10.11969/j.issn.1673-548X.2015.08.011 |
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| 基金项目:国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2012039);国家中医药行业科研专项基金资助项目(201207001) |
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| 中文摘要:目的 分析多囊卵巢综合征 (PCOS) 患者体重、胰岛素抵抗(IR)对脂代谢的影响。 方法 纳入符合2003年鹿特丹标准 PCOS患者47例,健康女性对照组30例。比较PCOS患者与健康女性脂代谢指标总胆固醇(TC)、 甘油三酯(TG)、低密度脂蛋白胆固醇 (LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A(APO-A)、载脂蛋白B(APO-B)、载脂蛋白B/载脂蛋白A(APO-B/APO-A)的差异。PCOS组根据体重指数(BMI)≥25kg/m2、胰岛素抵抗指数(HOMA-IR)>2.69,分为肥胖与非肥胖亚组,胰岛素抵抗与非胰岛素抵抗亚组。比较各亚组内TC、TG、LDL-C、HDL-C、APO-A、APO-B的差异,分析体重、胰岛素抵抗对脂代谢的影响。 结果 PCOS组各项脂代谢指标均高于与正常对照组,且TC、HDL-C、APO-A、APO-B/APO-A有显著差异(P<0.05);肥胖与非肥胖亚组比较,肥胖组脂代谢紊乱更重,HDL-C、APO-A、APO-B、APO-B/APO-A差异有统计学意义(P<0.05);伴随胰岛素抵抗的PCOS患者的脂代谢异常情况也远重于非胰岛素抵抗者,HDL-C、APO-B/APO-A差异有统计学意义(P<0.05)。 结论 PCOS患者脂代谢紊乱与肥胖和胰岛素抵抗密切相关。 |
| 中文关键词:多囊卵巢综合征 脂代谢 体重指数 胰岛素抵抗 |
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| Effect of Obesity and Insulin Resistance Factor on Lipid Metabolism in Women with Polycystic Ovary Syndrome |
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| Abstract:Objective To analyse the effect of obesity and insulin resistance on influence of lipid metabolism in women with polycystic ovary syndrome (PCOS). Methods Totally 47 patients with PCOS eligible Rotterdam standard were selected as the research object, and 30 cases of healthy women as control group. The differences of lipid metabolism index induding total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoprotein (APO-A), apolipoprotein B (APO-B) be tween PCOS patients and healthy women were compared.According to BMI≥25kg/m2,HOMA-IR>2.69, these patients were divided into obese and non-obese subgroup, and subgroup IR and NIR. The differences of the TC, TG, LDL-C, HDL-C, APO-A, APO-B amorg various subgroups were compared.The relationship between weight,insulin resistance and lipid metabolism was analyzed. Results The lipid metabolism indexes in PCOS group were higher than those in normal control group, and TC, HDL-C, APO-A, APO-B/APO-A existed significantly statistical difference (P<0.05).Compared with non-obese subgroup group, lipid metabolism disorder was heavier,and HDL-C, APO-A, APO-B, APO-B/APO-A existed significant statistical difference (P<0.05).PCOS patients With abnormal insulin resistance was far more heavier than those with no-insulin resistance in lipid metabolism. HDL-C, APO-B/APO-A existed significant statistical difference (P<0.05). Conclusion The patients with PCOS lipid metabolism disorder is closely related to obesity and insulin resistance. |
| keywords:Polycystic ovary syndrome Lipid metabolism Body mass index Insulin resistance |
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