| 调强放疗模式下青年鼻咽癌患者的预后分析 |
| 投稿时间：2014-12-18 修订日期：2015-01-09 点此下载全文 |
| 引用本文：陈荔莎,张恩环,吴君心,许雨虹,陈传本.调强放疗模式下青年鼻咽癌患者的预后分析[J].医学研究杂志,2015,44(8):45-48 |
| DOI：
10.11969/j.issn.1673-548X.2015.08.014 |
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| 基金项目:福建省自然科学基金资助项目(2010J01137) |
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| 中文摘要:目的 探讨调强放疗(intensity-modulated radiotherapy,IMRT)模式下青年鼻咽癌患者的生存分析与预后因素。 方法 回顾性分析2004年1月~2007年12月在笔者医院接受IMRT的青年鼻咽癌患者(年龄≤35岁)的临床资料,进行相关预后分析。 结果 101例患者5年无局部区域复发生存率、总生存率(OS)、无远处转移生存率(DFFS)及无瘤生存率(DFS)分别为93.8%、85.0%、79.9%和76.6%。多因素分析表明N分期是OS(P=0.018)、DFFS(P=0.001)及DFS(P=0.003)的独立预后因素。性别在本研究中是DFFS(P=0.050)的独立预后因素。 结论 IMRT治疗青年鼻咽癌可获得较好的局部区域控制率及总生存率,N分期是影响青年鼻咽癌调强放疗远期疗效的相关预后因素,远处转移是治疗失败的主要原因。 |
| 中文关键词:青年鼻咽肿瘤 放射疗法 调强适行 预后 |
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| Prognostic Analysis of Intensity-modulated Radiotherapy (IMRT) for Nasopharyngeal Carcinoma in Young Adult Patients |
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| Abstract:Objective To evaluate the treatment outcome and prognostic factors of young adults with nasopharyngeal carcinoma under intensity-modulated radiotherapy(IMRT). Methods One hundred and one nasopharyngeal carcinoma patients of young adults (35 years old or below) who were treated by IMRT at our institution from January 2004 to December 2007 were reviewed and analyzed. Results The median follow-up for all 101 patients was 70.3 months (range, 7.5-110.5 months).The 5-year local-regional recurrence-free survival (LRRFS), overall survival (OS), distant metastasis free survival (DMFS), and disease-free survival (DFS) were 93.8%, 85.0%, 79.9% and 76.6%, respectively. Multivariate factors analyses revealed that N classification was the significant prognosticator for OS (P=0.018), DMFS (P=0.001),DFS (P=0.003) and gender was an independent prognostic factor for DMFS (P=0.050). Chemotherapy failed to benefit treatment outcome (P>0.05). Conclusion Intensity-modulated radiotherapy seems to lengthen 5-year OS and to achieve a reasonable local-regional control in young adults nasopharyngeal carcinoma patients. N classification was the related prognostic factor influencing the long-term curative effect of IMRT of the youth with nasopharyngeal carcinoma, and distant metastasis remained the dominant failure pattern of our series. |
| keywords:Youth with nasopharyngeal neoplasm Radiotherapy Intensity-modulation plan Prognosis |
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