| 急性低血糖增加大鼠室性心律失常发生风险的研究 |
| 投稿时间：2014-11-20 修订日期：2014-12-20 点此下载全文 |
| 引用本文：王光宇,叶婷婷,张庆勇.急性低血糖增加大鼠室性心律失常发生风险的研究[J].医学研究杂志,2015,44(8):95-98,107 |
| DOI：
10.11969/j.issn.1673-548X.2015.08.029 |
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| 中文摘要:目的 探讨糖尿病大鼠发生急性低血糖时,室性心律失常发生的风险及其机制。 方法 用链脲佐菌素(STZ)腹腔注射方法制备糖尿病大鼠(DM)模型,将造模成功的大鼠(随机血糖>19.4mmol/L)饲养4周后随机分为糖尿病高血糖组 (DM组,n=9)和糖尿病低血糖组(DMHY组,n=9),同时将同一批次正常大鼠随机分为正常血糖组(N组,n=9),正常大鼠低血糖组(NHY组,n=9)。DMHY组和NHY组分别给予腹腔注射8U/kg剂量的胰岛素。DM组和N组则给予同体积生理盐水腹腔注射。当血糖<3.0mmol/L时,开胸给予在体电生理刺激。 结果 与N组相比,DM组血糖水平明显升高,体重明显降低,心肌重量也明显减少,室性心律失常的诱发率也明显增加。糖尿病4周后与N组相比,DM组QTc间期延长,但差异无统计学意义(P>0.05);同时诱发的室性快速心律失常(IVT)发生率增高,心室颤动阈值明显降低(9.25±0.56 vs 5.56±1.45,P均<0.05)。与N组相比,NHY组K+、肾上腺素及去甲肾上腺素水平差异有统计学意义(P<0.05)。 结论 糖尿病大鼠本身室性心律失常发生率明显比正常大鼠高;当发生急性低血糖时,室性心律失常的发生率明显增加,急性低血糖时降低了心室颤动阈值从而促进室性心律失常的发生,血钾降低、肾上腺素及去甲肾上腺素的升高也参与了心律失常的发生。 |
| 中文关键词:低血糖 糖尿病 心律失常 心室颤动阈值 |
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| Study of Acute Hypoglycemia Increases the Risk of Ventricular Arrhythmias in Rat |
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| Abstract:Objective To investigate the effect of acute hypoglycemia in diabetic rats on ventricular arrhythmias, and the potential mechanisms of ventricular arrhythmias. Methods Diabetic rats were induced by a single intraperitoneal injection streptozotocin(STZ), the successful model of rats (random blood glucose>19.4mmol/L) after feeding four weeks were randomly divided into diabetic hyperglycemia group(DM group, n=9), diabetic hypoglycemia group (DMHY group, n=9). While the same batch of normal rats were randomly divided into normal group (N group, n=9), normal hypoglycemia group (NHY group, n=9). DMHY group and NHY group were given intraperitoneal injection 8U/kg dose of insulin. DM and N group were given the same volume of saline. When blood glucose <3.0mmol/L, the thorax was opened and programmed electrophysiological stimulation (PES)-induced arrhythmias. Results Compared with the N group, blood glucose levels was significantly increased, while body weight and myocardial weight were significantly reduced in the DM group. Although QTc interval was prolonged in DM group, no significant difference between DM group and N group(P>0.05); the incidence of ventricular arrhythmias was significantly increased and ventricular fibrillation threshold was greatly decreased(9.25±0.56 vs 5.56±1.45,P<0.05) in the DM group. With regard to K+、E and NE levels, there is a significant difference between N group and NHY group (P<0.05). Conclusion The incidence of ventricular arrhythmia in diabetic rats was significantly higher than in normal rats. Under acute hypoglycemia conditions, the incidence of ventricular arrhythmias was increased significantly and ventricular fibrillation threshold was significantly reduced, thereby contribute to ventricular arrhythmias. In addition, blood potassium decreased, epinephrine and norepinephrine increased were also involved in arrhythmias. |
| keywords:Hypoglycemia Diabetic Arrhythmia Ventricular fibrillation threshold |
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