OSAHS患者血清MIF水平的变化及意义
投稿时间:2015-01-06  修订日期:2015-01-14  点此下载全文
引用本文:张淑文,赵国锋,许玉静,李明,刘亚辉,李林旭,张蕊,王红阳.OSAHS患者血清MIF水平的变化及意义[J].医学研究杂志,2015,44(8):159-161
DOI: 10.11969/j.issn.1673-548X.2015.08.046
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作者单位
张淑文 063000 河北省唐山市协和医院呼吸科 
赵国锋 063000 河北省唐山市协和医院耳鼻喉科 
许玉静 063000 河北省唐山市协和医院耳鼻喉科 
李明 063000 河北省唐山市协和医院呼吸科 
刘亚辉 063000 河北省唐山市协和医院检验科 
李林旭 063000 河北省唐山市协和医院呼吸科 
张蕊 063000 河北省唐山市协和医院检验科 
王红阳 063000 唐山, 河北联合大学附属医院呼吸科 
中文摘要:目的 探讨阻塞型睡眠呼吸暂停低通气综合征(OSAHS)患者血清MIF浓度变化及与糖代谢的关系,进一步探讨OSAHS患者发病机制。 方法 选择经多导睡眠监测(PSG)确诊的OSAHS患者[睡眠呼吸暂停低通气指数(AHI≥5次/小时)]66例作为病例组,25例单纯打鼾患者(AHI<5次/小时)作为对照组,测定并比较上述两组的血清MIF及糖代谢指标的差异,并分析OSAHS患者血清MIF及糖代谢各指标的相关性。 结果 ①OSAHS患者的血清MIF浓度水平高于正常对照组,差异有统计学意义;②OSAHS患者的FPG、FINS、MIF与AHI呈正相关(r分别为0.508、0.411、0.449,P<0.01),与LSpO2呈负相关(r分别为-0.380、-0.287、-0.405,P<0.01)。OSAHS患者的ISI与AHI呈负相关(r=-0.493),与LSpO2呈正相关(r=0.486)。OSAHS患者的FPG与MIF呈正相关(r=0.255, P<0.05),MIF与BMI无关(r=0.198, P>0.05)。 结论 OSAHS患者存在炎性反应, 并且存在糖代谢紊乱,血清MIF可能参与了OSAHS患者糖代谢紊乱。
中文关键词:OSAHS  MIF  代谢紊乱
 
Changes and Significance of Serum MIF Levels in OSAHS of Patients
Abstract:Objective To explore the association of serum MIF and carbohydrate metabolism in patients with OSAHS,and to investigate the pathogenesis of OSAHS. Methods Patients were divided into two groups, 66 cases of patients with OSAHS diagnosed by polysomnography (PSG) (AHI≥5 times/h) as the patient group, 25 cases of simple snoring patients (AHI<5 times/h) as the control group.Determine and compare the differences between serum MIF and the indicators of carbohydrate metabolism in the two groups, and analyze the correlation between serum MIF and the indicators of carbohydrate metabolism. Results Compared with the levels of MIF between OSAHS group and the control group, the OSAHS group was higher than the control group, the difference was statistically significant (P<0.05). FPG, FINS, MIF in OSAHS group have positive correlation with AHI(r=0.508, 0.411, 0.449, P<0.01), and negative correlation with LSpO2(r=-0.380,-0.287,-0.405, P<0.01). ISI has negative correlation with AHI in OSAHS group(r=-0.493),and positive correlation with AHI(r=0.486).MIF has positive correlation with FPG in OSAHS group, and is unrelated with BMI. Conclusion There is inflammation and abnomal carbohydrate metabolism in patients with OSAHS.Serum MIF may be involved in abnomal carbohydrate metabolism.
keywords:OSAHS  MIF  Metabolic disorders
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