| 脑心通胶囊对脑梗死患者神经功能的影响及其相应机制的研究 |
| 投稿时间：2014-11-02 修订日期：2014-11-24 点此下载全文 |
| 引用本文：陈茂华,朱迪海.脑心通胶囊对脑梗死患者神经功能的影响及其相应机制的研究[J].医学研究杂志,2015,44(8):162-164 |
| DOI：
10.11969/j.issn.1673-548X.2015.08.047 |
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| 中文摘要:目的 观察脑心通胶囊对脑梗死患者脑血管血流动力学参数的影响以及临床疗效,并探讨相关的作用机制。 方法 收集建德市第二人民医院2009年1月~2014年1月神经内科收治的急性脑梗死患者200例,分为常规治疗对照组和脑心通胶囊治疗观察组,每组100例,观察组在常规治疗的基础上口服脑心通胶囊。心脑血管检测仪检测脑血管血流动力学参数。化学比色测定法测定一氧化氮合酶(NOS) 活性,硝酸还原酶法检测一氧化氮(NO) 表达。 结果 两组治疗前血流平均速度、平均血流量、脑血管阻力差异无统计学意义(P>0.05),治疗后两组血流平均速度和平均血流量均显著升高(P<0.05),脑血管阻力均显著减低(P<0.05),但观察组对脑血管血流动力学参数的改善作用显著优于对照组(P<0.05)。两组治疗前NOS活性和NO表达差异无统计学意义(P>0.05),治疗后两组NOS 活性和NO表达均显著减低(P<0.05和P<0.01),但观察组治疗后NOS 活性和NO表达均显著高于对照组(P<0.05)。对照组临床治疗有效率为73.0%,显著低于观察组的90.0%(P<0.05)。两组治疗前FMA和Sheikh评分差异无统计学意义(P>0.05),3个月后FMA和Sheikh评分均显著升高(P<0.05和P<0.01),但观察组对FMA和Sheikh评分的改善作用显著优于对照组(P<0.05)。 结论 脑心通胶囊可以显著增加脑血流量,有助于损伤神经功能的恢复,临床疗效显著,升高NOS 活性和NO 表达可能是其起效的主要作用机制。 |
| 中文关键词:脑心通胶囊 脑梗死 一氧化氮合酶 一氧化氮 |
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| Clinical Efficacy of Naoxintong Capsules on Nervous Function Recovery in Patients with Cerebral Infarction and Its Corresponding Mechanism |
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| Abstract:Objective To investigate the effect of Naoxintong capsule on clinical efficacy and cerebral vascular hemodynamic parameters in patients with cerebral infarction, and explore the mechanism. Methods A total of 200 patients with cerebral infarction were enrolled in this study. Patients were divided into control group and Naoxintong capsule observation group. Treatment of Observation group was on the basis of conventional treatment of oral Naoxintong capsule.Cardiovascular detector was used to detect cerebrovascular hemodynamic parameters. NOS activity was determined by chemical colorimetric assay. NO was determined by nitrate reductas method. Results Before treatment, there was no significant difference in average blood flow speed, average blood flow, and cerebral vascular resistance between the two groups (P>0.05). After treatment, average blood flow speed and average blood flow was increased and erebral vascular resistance was decreased in the two groups(P<0.05). However, the improvement was better in observation group than that in control group (P<0.05). Before treatment, there was no significant different of NOS activity and NO expression between the two groups (P>0.05). After treatment, There were decreased in the two groups(P<0.05 and P<0.01). However, NOS activity and NO expression was higher in observation group than that in control group (P<0.05). The clinic effect in control group was 73.0%, which was significantly lower than 90.0% in observation group(P<0.05). Before treatment, there was no significant different of FMA and Sheikh score between the two groups (P>0.05). After treatment, they were increased in the two groups(P<0.05 and P<0.01). However, FMA and Sheikh score was higher in observation group than that in control group (P<0.05). Conclusion Naoxintong capsule can significantly increase cerebral blood flow, and contribute to recovery of nerve function injury, with has remarkablely clinical effect. The increasing of NOS activity and NO expression may be the main mechanismt. |
| keywords:Naoxintong capsule Cerebral infarction NOS NO |
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