| 羟氯喹对类风湿关节炎患者关节滑液IL-1α和IL-6表达影响的研究 |
| 投稿时间：2015-01-02 修订日期：2015-01-23 点此下载全文 |
| 引用本文：张舸,杨群智,付爽,费雅楠.羟氯喹对类风湿关节炎患者关节滑液IL-1α和IL-6表达影响的研究[J].医学研究杂志,2015,44(9):100-102 |
| DOI：
10.11969/j.issn.1673-548X.2015.09.028 |
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| 基金项目:国家自然科学基金资助项目(81273309) |
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| 中文摘要:目的 探讨羟氯喹对类风湿关节炎患者关节滑液中IL-1α 和IL-6的影响。 方法 选取类风湿关节炎患者60例,分为A组羟氯喹治疗组,B组甲氨蝶呤治疗组,C组甲氨蝶呤和羟氯喹联合治疗组,追踪随访1年,观察药物疗效、不良反应以及比较用药前后,类风湿患者关节滑液中IL-1α 和IL-6水平的变化。 结果 经治疗后C组的有效率明显高A组B组;A组与B组相比较,两组的疗效比较差异无统计学意义;A组治疗的不良反应最少;治疗后,关节滑液检测IL-1α 和IL-6的水平降低,且A组降低的水平与B组接近。 结论 证实单独使用羟氯喹对类风湿关节炎的抗炎效果明显,且甲氨蝶呤与羟氯喹合用的作用更强,从治疗的角度考虑,羟氯喹的不良反应小,更适合于临床需长期治疗的类风湿关节炎患者。 |
| 中文关键词:类风湿关节炎 甲氨蝶呤 羟氯喹 IL-1α IL-6 |
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| Level of IL-1α and IL-6 in Joint Synovial of Rheumatoid Arthritis by Treatment with Hydroxychloroquine |
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| Abstract:Objective To investigate the level of IL-1α and IL-6 in the synovial of joint treated with hydroxychloroquine. Methods Sixty patients were acted as three groups: those in A group were treated with hydroxychloroquine, in B group were treated with methotrexate and in C group were treated with hydroxychloroquine couples with methotrexate. The clinical symptoms and side effects of these treatments were evaluated for 1 year. The level of IL-1α and IL-6 were further detected. Results After these treatments, the effective power was best in C group compared with A group and B group, and there was no significant difference between A group and B group. The side effect was least in A group. The level of IL-1α and IL-6 in synovial of joint was obviously decreased in A group. Conclusion Hydroxychloroquine was a good choice to rheumatoid arthritis, especially to the long-turm use,which has obvious anti-inflammation actiion and small side effects. |
| keywords:Rheumatoid arthritis Methotrexate Hydroxychloroquine IL-1α IL-6 |
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