系统性硬化病血脂和同型半胱氨酸水平异常的临床研究
投稿时间:2014-12-22  修订日期:2015-02-06  点此下载全文
引用本文:李鞠,刘焱,孟德钎,蒋真,李永胜,潘文友.系统性硬化病血脂和同型半胱氨酸水平异常的临床研究[J].医学研究杂志,2015,44(9):121-125
DOI: 10.11969/j.issn.1673-548X.2015.09.034
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作者单位E-mail
李鞠 223300 江苏省淮安市第一人民医院免疫风湿科  
刘焱 223300 江苏省淮安市第一人民医院免疫风湿科  
孟德钎 223300 江苏省淮安市第一人民医院免疫风湿科  
蒋真 223300 江苏省淮安市第一人民医院免疫风湿科  
李永胜 223300 江苏省淮安市第一人民医院免疫风湿科  
潘文友 223300 江苏省淮安市第一人民医院免疫风湿科 liju198461@163.com 
中文摘要:目的 探讨系统性硬化病(SSc)患者血脂和同型半胱氨酸(Hcy)的变化及其与病情活动度的关系。 方法 对65例SSc患者和65名年龄、性别配对的健康体检者(对照组)的甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(VLDL-C)、血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)等的水平进行检测分析,并根据血脂情况把SSc患者分为高脂血症组和非高脂血症组,利用统计软件检验各组之间的差异,并进行相关分析。 结果 与对照组相比,SSc患者TG(P=0.000)、VLDL-C(P=0.000)升高,总胆固醇(P=0.025)、LDL-C(P=0.038)及HDL-C(P=0.000)下降。SSc患者高Hcy血症和高血脂率分别为69.23%和38.46%。血清Hcy水平与皮肤厚度总分值(r=0.759,P=0.006)和CRP(r=0.398,P=0.028)水平呈正相关,血清HDL-C水平与SSC疾病严重程度Valentini评分(r=-0.319,P=0.0413)和CRP(r=-0.270,P=0.045)呈负相关,而Hcy水平与TG、TC水平无明显相关性(P>0.05)。 结论 SSc 患者的血脂和Hcy的异常与疾病活动度有关,这有可能增加SSc患者发生心血管不良事件的风险。
中文关键词:系统性硬化病  高脂血症  同型半胱氨酸  炎症
 
Clinical Significance of Blood Lipids and Blood Homocystein in Patients with Systemic Sclerosis
Abstract:Objective To investigate the changes of serum lipids and homocysteine in patients with systemic sclerosis (SSc) and the correlation between the changes and activity of SSc. Methods Sixty five cases with SSc and 65 normal individuals (control group) were enrolled. The level of serum triglyceride(TG),total cholesterol(TC),high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VDLC-C), homocysteine (Hcy) and C-reaction protein were determined.SSc patients were divided into hyperlipidemia group and non-hyperlipidemia group.Comparison of these data between groups was analyzed by SPSS 18.0. The corrections between variables were also analyzed. Results The levels of TG(P=0.000),VLDL-C(P=0.000) were significantly higher than that of controls. The levels of HDL-C(P=0.000), TC(P=0.025) and LDL-C (P=0.038)in SSc were significantly lower than those of controls. The rate of Hcy and elevated serum lipid was 69% and 38.46%, respectively.Spearman's correlation test demonstrated that Hcy levels correlated positively with TSS(r=0.759,P=0.006) and serum CRP(r=0.398,P=0.028). The levels of HDL-C correlated negatively with Valentini scores of SSc (r=-0.319,P=0.041)and CRP(r=-0.270,0.045). The levels of serum Hcy were not significantly correlated with TG and TC(P>0. 05). Conclusion Hcy and blood lipid levels are associated with the level of disease activity in patients with SSc, which may increase the risk of adverse cardiovascular prognosis in patients with SSc.
keywords:Systemic sclerosis  Serum lipid  Homocysteine  Inflammation
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