| 慢性阻塞性肺部疾病急性加重期患者的红细胞分布宽度与其30天预后的相关性 |
| 投稿时间：2015-02-06 修订日期：2015-02-26 点此下载全文 |
| 引用本文：陈思佳,王飞,胡善友,吴晓.慢性阻塞性肺部疾病急性加重期患者的红细胞分布宽度与其30天预后的相关性[J].医学研究杂志,2015,44(10):80-82 |
| DOI：
10.11969/j.issn.1673-548X.2015.10.022 |
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| 基金项目:上海市嘉定区卫生系统第三批重点学科建设基金资助项目(ZD01);上海市嘉定区中心医院第十一批中青年骨干培养计划基金资助项目 |
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| 中文摘要:目的 探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者的红细胞分布宽度(RDW)的水平与其30天预后的相关性。 方法 选择2012年11月~2014年8月在上海市嘉定区中心医院急诊科就诊的499例已诊断为COPD并因急性发作入院的患者,根据临床转归分为存活组(n=463)和死亡组(n=36),比较两组患者的临床资料及其实验室指标的差异性。再根据RDW中位数水平分为RDW低值组(n=250)和RDW高值组(n=249),比较两组30天预后的差异,采用多元逐步回归分析预后不良的独立相关因素。 结果 死亡组患者的RDW水平[14.1(13.1~14.8) vs 15.0(13.2~16.2),P=0.005]显著高于存活组,同时年龄、白细胞计数及降钙素原亦显著增高(P<0.05)。RDW高值组的30天的病死率显著高于RDW低值组(10.0% vs 4.4%,P=0.016)。RDW水平(标准偏回归系数=0.116,P=0.015)、较差心功能(标准偏回归系数=0.23,P=0.000)及白细胞计数(标准偏回归系数=0.169,P=0.000)与AECOPD预后不良呈独立线性相关。 结论 RDW水平与 AECOPD患者的30天预后密切相关,对判断其预后有重要参考价值。 |
| 中文关键词:慢性阻塞性肺疾病急性加重期 红细胞分布宽度 预后 病死率 |
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| Red Cell Distribution Width and Prognosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients |
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| Abstract:Objective To investigate the correlation of red cell distribution width (RDW) with the prognosis of acute exacerbation of chronic obstructive pulmonary disease patients. Methods A total of 499 cases of acute exacerbation of chronic obstructive pulmonary disease diagnosed at admission in our emergency department from November 2012 to August 2014 were enrolled in this study. The patients were divided into survival group(n=463)and death group(n=36)based on their clinical outcomes. The general clinical data, laboratory parameters, and mortality were compared between the 2 groups. They were divided into 2 groups according to their RDW median levels. Prognosis of 30 days was compared between the two groups. The correlation between RDW and poor outcomes were analyzed by Stepwise multiple regression analysis. Results The RDW level was significantly higher in deathgroup than that in the survival group[14.1(13.1-14.8) vs 15.0(13.2-16.2),P=0.005],and age,WBC, PCT were also significantly higher in death group than those in the survival group(P<0.05).The mortality was significantly higher in the high-level RDW group than that in the low-level RDW group (10.0% vs 4.4%, P=0.016). Stepwise multiple regression analysis indicated RDW(standard partial regression coefficient=0.116,P=0.015), heart failure (standard partial regression coefficient=0.23,P=0.000) and WBC(standard partial regression coefficient=0.169,P=0.000) had positive correlations with poor outcome in the patients. Conclusion RDW level at admission in acute exacerbation of chronic obstructive pulmonary disease patients is closely correlated with the prognosis of 30days, and shows an important predictive value in the prognosis of the patients. |
| keywords:Chronic obstructive pulmonary disease with acute exacerbation Red blood cell distribution width Prognosis Mortality |
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