| 强直性脊柱炎患者血清补体B因子及免疫球蛋白测定的临床意义 |
| 投稿时间：2015-01-08 修订日期：2015-03-04 点此下载全文 |
| 引用本文：陈兵华,王峰,邬丽娜,秦玲.强直性脊柱炎患者血清补体B因子及免疫球蛋白测定的临床意义[J].医学研究杂志,2015,44(10):135-137 |
| DOI：
10.11969/j.issn.1673-548X.2015.10.038 |
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| 中文摘要:目的 探讨血清中补体B因子及免疫球蛋白IgA、IgG、IgM含量的检测在强直性脊柱炎(AS)诊疗中的应用价值。 方法 在全自动特定蛋白分析仪上采用免疫速率散射比浊法测定AS患者组及健康对照组血清中补体B因子(CFB)及免疫球蛋白IgA、IgG、IgM含量,流式细胞术分析两组人群HLA-B27表达情况,进一步分析指标间的关系。 结果 AS患者组HLA-B27阳性率极高,且血清中CFB、IgA 和IgG含量均增高,与对照组相比差异有统计学意义(P<0.01),AS患者血清CFB升高与免疫球蛋白升高无明显相关性(P>0.05),而IgA和IgG含量升高有一定程度相关性(P<0.05)。 结论 血清中CFB及免疫球蛋白IgA、IgG、IgM含量的检测对AS的临床诊断和治疗提供重要的依据。 |
| 中文关键词:强直性脊柱炎 补体B因子 免疫球蛋白类 自身免疫性疾病 |
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| Clinical Value of Detecting Serum Complement Factor B and Immunoglobulins in Patients with Ankylosing Spondylitis |
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| Abstract:Objective To detect the serum levels of complement factor B and immunoglobulins in patients with ankylosing spondylitis (AS), and analyze application value in the diagnosis and treatment of AS. Methods Immune rate nephelometry was used to detect complement factor B and immunoglobulins on Immage® 800 Rate Nephelometer (Beckman Coulter Inc. Brea, CA, USA),and HLA-B27 was measured in AS and health controls. Results The positive rate of HLA-B27 was extremely high in AS patients.Serum complement factor B and immunoglobulins(IgA and IgG)in AS patients were significantly higher than those of health controls(P<0.01). And the elevated concentration of CFB in AS patients had no significant correlation with those of serum immunoglobulins, while there was certainly positive correlation between the increased serum level of IgA and those of IgG. Conclusion Detecting the concentration of CFB and immunoglobulins(IgA,IgG and IgM) provides an important basis for clinical diagnosis and treatment of AS. |
| keywords:Ankylosing spondylitis CFB Immunoglobulin Autoimmune disease |
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