| 病毒性肝炎与获得性再生障碍性贫血关系的病例-对照研究Meta分析 |
| 投稿时间：2015-03-24 修订日期：2015-04-07 点此下载全文 |
| 引用本文：胡南霞,刘毅,李艳君,丁毅伟,郭宏岗,沈建良,马聪.病毒性肝炎与获得性再生障碍性贫血关系的病例-对照研究Meta分析[J].医学研究杂志,2015,44(11):105-110 |
| DOI：
10.11969/j.issn.1673-548X.2015.11.030 |
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| 中文摘要:目的 探讨病毒性肝炎与获得性再生障碍性贫血的关系。方法 通过制定相关的检索策略,网络检索Cochrane Library、PubMed、EMBASE、Ovid、中国生物医学文献、CNKI、万方数据库、重庆维普等数据库;检索时间均从建库~2014年12月。纳入所有有关研究病毒性肝炎和获得性再生障碍性贫血病因相关性的病例-对照研究,并利用Newcastle-Ottawa Scale(NOS)文献评价量表对所纳入的文献进行评价。采用Stata12.0软件对同质性较好的研究进行Meta分析。结果 最终有8篇病例对照研究纳入Meta分析,其中2篇可能给纳入文献带来异质性,分别对纳入的8篇文献及剔除可能带来异质性的两篇文献后的6篇文献进行Meta分析,再生障碍性贫血组与对照组的人群比较Meta分析结果显示,合并效应量分别为OR=2.41(95%CI:1.40~4.41)和OR=2.24(95%CI:1.35~3.71)。均表明有病毒性肝炎病史者发生再生障碍性贫血的危险性是无病毒性肝炎病史者的2倍。结论 病毒性肝炎与获得性再生障碍性贫血的发生呈正相关,提示病毒性肝炎可能是获得性再生障碍性贫血的一个危险因素。 |
| 中文关键词:病毒性肝炎 获得性再生障碍性贫血 病例-对照研究 Meta分析 |
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| Association between Viral Hepatitis and Acquired Aplastic Anemia:A Meta-analysis of Case-control Study. |
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| Abstract:Objective To evaluate the association between viral hepatitis and acquired aplastic anemia. Methods Original literatures for this review were searched with Cochrane Library, PubMed, EMBASE, Ovid, CBMdisc, CNKI, etc. from database establishment to November 2014. All the case-studies on the association between Viral hepatitis and acquired aplastic anemia were included and assessed by Newcastle-Ottawa quality assessment scale. Meta-analysis was conducted by Stata12.0 software. Results A total of 8 case-control studies were submitted to the meta-analysis, including 2 studies may induce heterogeneity. All of the 8 studies and the 6 studies without 2 that may increasing heterogeneity were respectively conducted by the meta-analysis. The results showed that the pooled odds ratio(OR) of aplastic anemia group were 2.41(95%CI:1.40-4.41) and 2.24(95%CI:1.35-3.71) compared with the control group. Our results demonstrated that the viral hepatitis might increase the risk of acquired aplastic anemia morbidity nearly 2-fold compared with control group. Conclusion Our analysis shows a positive association between viral hepatitis and acquired aplastic anemia, suggesting that viral hepatitis may be a risk factor for aplastic anemia. |
| keywords:Viral hepatitis Acquired aplastic anemia Case-control study Meta-analysis |
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