| IL-17及其家族成员在PCI术后再狭窄中作用的研究 |
| 投稿时间：2015-04-16 修订日期：2015-05-08 点此下载全文 |
| 引用本文：唐其柱,刘高瞻,刘文卫.IL-17及其家族成员在PCI术后再狭窄中作用的研究[J].医学研究杂志,2015,44(12):51-54 |
| DOI：
10.11969/j.issn.1673-548X.2015.12.014 |
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| 基金项目:湖北省自然科学基金资助项目(2012FFA071);中国医师协会阳光心血管研究基金资助项目(201202);襄阳市科技计划研究与开发项目(2012[40]10) |
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| 中文摘要:目的探讨IL-17及其家族成员在冠脉支架植入术后再狭窄中的作用。方法共纳入52例患者,以曾行冠脉支架植入术并复查冠脉造影的30例患者作为观察组,以同期胸痛、心悸等症状入院行冠脉造影排除冠心病的22例患者作为对照组,观察组根据复查冠脉造影时支架内再狭窄的程度分为再狭窄组12例和无再狭窄组18例。所有入选患者均于冠脉造影术前采血,记录两组患者的一般情况、生化指标及冠脉病变情况等。测定并比较:1观察组和对照组患者血清IL-17的水平;2再狭窄组和无再狭窄组患者血清IL-17水平;3再狭窄组和无再狭窄组患者血清IL-17A、IL-17B、IL-17C、IL-17D、IL-17F的水平;4对可能与再狭窄有关的因素进行回归分析。结果1观察组IL-17水平显著高于对照组(P<0.05);2再狭窄组IL-17水平较无再狭窄组高,但差异无统计学意义(P>0.05);3再狭窄组IL-17A水平显著高于对照组(P<0.05),而IL-17B、IL-17C、IL-17D、IL-17F在两组患者中差异均无统计学意义(P>0.05);4Logistic回归分析结果示,冠脉支架植入术后再狭窄的发生与患者的年龄、性别等一般情况及IL-17水平无关,只与IL-17A有关。结论IL-17可能参与冠脉支架植入术后的慢性炎性反应,同时研究发现IL-17A与再狭窄的发生关系密切,是冠脉支架内再狭窄的独立危险因素,IL-17A的水平可作为预测再狭窄的指标,可在复查冠脉造影前对患者进行危险分层。 |
| 中文关键词:白介素17 白介素17家族 冠状动脉 支架内再狭窄 |
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| Study on the Effect of IL-17 and Family Members in In-stent Restenosis after PCI. |
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| Abstract:Objective To investigate the role of IL-17 and its family members in restenosis after coronary stent implantation. Methods A total of 52 patients were enrolled. Thirty patients were selected as the observation group who underwent coronary stenting and review coronary angiography, and 22 patients were selected with chest pain, palpitations and other symptoms who underwent coronary angiography and were excluded coronary heart disease as control group. According to the coronary angiography, the observation group was divided into restenosis group in 12 cases and non-restenosis group in 18 cases. Blood samples were collected for all patients before they underwent coronary angiography. Meantime, we recorded the general condition of patients in the two group, the biochemical indexes and coronary artery lesions, then determined and compared:IL-17 serum level of patients in the observation group and the control group; IL-17 serum level of patients in the restenosis group and non-restenosis group; IL-17A,IL-17B,IL-17C,IL-17D,IL-17F subtypes serum level of patients in the restenosis group and non-restenosis group; the possible factors associated with restenosis by regression analysis. Results The IL-17 level of the observation group was significantly higher than that of the control group (P<0.05). The IL-17 level of the restenosis group was higher than that of the non-restenosis group, but the difference between them was not statistically significant (P>0.05). The level of IL-17A of the restenosis group was significantly higher than that of the control group (P<0.05), however, the difference between the level of IL-17B, IL-17C, IL-17D and IL-17F in the two groups of patients had no significant(P>0.05). The results of the Logistic regression analysis showed that coronary restenosis was only related to IL-17A level, neither was the patient's age, gender and level of IL-17. Conclusion IL-17 may be involved in the chronic inflammatory response after coronary stent implantation. IL-17A is found closely associated with restenosis, and it is an independent risk factor of coronary artery in-stent restenosis. The level of IL-17A can be used as a predictive index of restenosis, and also can be used to make risk stratification of patients before they undergo coronary angiography. |
| keywords:Interleukin-17 IL-17 family Coronary artery In-stent restenosis |
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